Results 241 to 250 of about 77,584 (306)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap. [PDF]

Molecules
Zhang H, Shen Q, Hu Z, Wu PQ, Chen Y, Zhao JX, Yue JM.   +6 more
europepmc   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients. [PDF]

Trends Mol Med
Mozzetta C, Sartorelli V, Steinkuhler C, Puri PL.   +3 more
europepmc   +1 more source

Intensive Chemotherapy With or Without Midostaurin in Adults ≥ 60 Years Old With FLT3‐Mutated AML: A FILO‐DATAML‐PETHEMA Real‐World Study

American Journal of Hematology, Volume 101, Issue 5, Page 949-960, May 2026.
ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Gaspar Aspas Requena, Pau Montesinos, Emilie Bérard, Sarah Bertoli, Rebeca Rodríguez‐Veiga, Celestine Simand, Laura Torres, Pierre Peterlin, Mar Tormo, Rudy Birsen, Juan Miguel Bergua‐Burgues, Emmanuelle Tavernier, Teresa Bernal del Castillo, Martin Carré, Cristina Gil, Adrien Contejean, Eduardo Rodríguez‐Arbolí, Corentin Orvain, Carlos Rodríguez‐Medina, Lauren Veronese, Maria Jose Sayas Lloris, Eric Delabesse, Josefina Serrano, Ariane Mineur, María García‐Fortes, Romain Guieze, Maria Luz Amigo, Arnaud Pigneux, Lorenzo Algarra Algarra, Christian Recher, Pierre‐Yves Dumas, David Martínez‐Cuadrón   +31 more
wiley   +1 more source

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers <b>DS-103</b> as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. [PDF]

J Med Chem
Stopper D, Biermann L, Watson PR, Li J, König B, Gaynes MN, Pessanha de Carvalho L, Klose J, Hanl M, Hamacher A, Schäker-Hübner L, Ramsbeck D, Held J, Christianson DW, Kassack MU, Hansen FK.   +15 more
europepmc   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids. [PDF]

J Med Chem
Chou PY, Lai MJ, Tsai KK, Cheng LH, Wu YW, Chen MC, Pan SL, Ho HO, Nepali K, Liou JP.   +9 more
europepmc   +1 more source

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source