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[Development of HDAC inhibitors].
Gan to kagaku ryoho. Cancer & chemotherapy, 2010In the mechanisms of carcinogenesis, it is becoming apparent that not only genetic abnormalities including DNA mutations, but also epigenetic abnormalities are heavily involved. Simultaneously, certain kinds of compounds indicated anti-tumor activity through their epigenetic effects.
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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Nature Biotechnology, 2011Marcus Bantscheff +2 more
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Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
Nature Reviews Drug Discovery, 2008Leslie M Thompson
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap +2 more
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