Results 31 to 40 of about 77,584 (306)
Pharmaceuticals, 2014 Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders.
Elizabeth A. Thomas
doaj +1 more source
Recent Update of HDAC Inhibitors in Lymphoma
Frontiers in Cell and Developmental Biology, 2020 Modulating epigenetic modification has been recognized for over a decade as an effective therapeutic approach to cancer and many studies of histone deacetylase (HDAC), one of the best known epigenetic modulators, have been published.
I-Chung Chen +2 more
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Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]
, 2005 The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R. +3 more
core +1 more source
Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors
Molecules, 2023 Multi-target drugs (MTDs) are emerging alternatives to combination therapies. Since both histone deacetylases (HDACs) and cyclooxygenase-2 (COX-2) are known to be overexpressed in several cancer types, we herein report the design, synthesis, and ...
Luisa M. Bachmann +7 more
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Anticancer Ruthenium Complexes with HDAC Isoform Selectivity
Molecules, 2020 The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may ...
Jasmine M. Cross +5 more
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Biomolecules, 2023 Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP ...
Yujie Dong +6 more
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Clinical Epigenetics, 2012 The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue homeostasis.
Delcuve Geneviève P +2 more
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Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. [PDF]
PLoS ONE, 2011 Aberrant histone deacetylase (HDAC) activity is frequent in human leukemias. However, while classical, NAD(+)-independent HDACs are an established therapeutic target, the relevance of NAD(+)-dependent HDACs (sirtuins) in leukemia treatment remains ...
Michele Cea +23 more
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Bone & Joint Research, 2022 Aims: In the repair of condylar cartilage injury, synovium-derived mesenchymal stem cells (SMSCs) migrate to an injured site and differentiate into cartilage.
Wen-ting Liao +7 more
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Quinolone-based HDAC inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 HDAC inhibitors emerged as promising drug candidates in combating wide variety of cancers. At present, two of the compounds SAHA and Romidepsin were approved by FDA for cutaneous T-cell lymphoma and many are in various clinical phases. A new quinolone cap structure was explored with hydroxamic acid as zinc-binding group (ZBG).
Gopalan, Balasubramanian +5 more
openaire +2 more sources