Results 41 to 50 of about 77,584 (306)
Current HDAC Inhibitors in Clinical Trials
CHIMIA, 2022 Epigenetic modifications in eukaryotic biological pathways can lead to the up- or downregulation of regulatory proteins contributing to disease onset and progression. In the last three decades, histone deacetylases (HDACs) are among the most studied epigenetic targets.
Elisabetta Di Bello +3 more
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PLoS ONE, 2012 Histone deacetylase (HDAC) inhibitors are being intensively pursued as potential new drugs for a range of diseases, including malaria. HDAC inhibitors are also important tools for the study of epigenetic mechanisms, transcriptional control, and other ...
Katherine T Andrews +5 more
doaj +1 more source
Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy
Pharmaceuticals, 2023 Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains poor.
Liesbeth Everix +4 more
doaj +1 more source
HDACs and HDAC Inhibitors in Cancer Development and Therapy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear architecture.
Yixuan, Li, Edward, Seto
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Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]
, 2010 [No abstract ...
CANETTIERI, Gianluca +4 more
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HDACs and HDAC inhibitors in colon cancer [PDF]
Epigenetics, 2008 The histone deacetylase (HDAC) family of transcriptional co-repressors have emerged as important regulators of colon cell maturation and transformation. Pharmacological inhibitors of class I and II HDAC activity (HDACi) are potent inducers of growth arrest, differentiation and apoptosis of colon cancer cells in vitro and in vivo, implicating a role for
openaire +2 more sources
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]
, 2018 Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina +11 more
core +3 more sources
HDAC Inhibitors in Acute Myeloid Leukemia [PDF]
Cancers, 2019 Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled proliferation, differentiation arrest, and accumulation of immature myeloid progenitors. Although clinical advances in AML have been made, especially in young patients, long-term disease-free survival remains poor, making this disease an unmet therapeutic challenge.
Edurne San José-Enériz +3 more
openaire +3 more sources
Pharmaceuticals, 2011 Friedreich’s ataxia (FRDA) is caused by transcriptional repression of the nuclear FXN gene encoding the essential mitochondrial protein frataxin. Based on the hypothesis that the acetylation state of the histone proteins is responsible for gene silencing
Joel M. Gottesfeld +4 more
doaj +1 more source
Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates [PDF]
, 2017 We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center.
Brabec, Viktor +8 more
core +1 more source