Results 81 to 90 of about 76,991 (209)

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

JCI Insight, 2023
Histone deacetylase (HDAC) inhibitors have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the blood-brain barrier, HDAC ...
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta   +12 more
doaj   +1 more source

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

Journal of Inflammation, 2010
Background Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC inhibitors ...
Adcock Ian M, Ito Misako, Jalonen Ulla, Ito Kazuhiro, Ilmarinen-Salo Pinja, Janka-Junttila Mirkka, Kankaanranta Hannu, Moilanen Eeva, Zhang Xianzhi   +8 more
doaj   +1 more source

Gene regulation and epigenotype in Friedreich's ataxia [PDF]

, 2008
Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core   +2 more sources

Sirtuin inhibitors reduce intracellular growth of M. tuberculosis in human macrophages via modulation of host cell immunity

Scientific Reports
Host-directed therapies aiming to strengthen the body’s immune system, represent an underexplored opportunity to improve treatment of tuberculosis (TB).
Sadaf Kalsum, Mira Akber, Marco Giulio Loreti, Blanka Andersson, Eva Danielson, Maria Lerm, Susanna Brighenti   +6 more
doaj   +1 more source

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939 [PDF]

, 2012
Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid [SAHA;
Andrews, Katherine T., Do, Tram Anh, Fairlie, David P., Goodman, Christopher D., Haque, Ashraful, Lucke, Andrew J., McFadden, Geoffrey I., Sahama, Ishani, Skinner-Adams, Tina, Sumanadasa, Subathdrage D. M.   +9 more
core   +1 more source

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types

OncoImmunology, 2018
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail to benefit most patients with carcinomas.
Kristin C. Hicks, Massimo Fantini, Renee N. Donahue, Angie Schwab, Karin M. Knudson, Sarah R. Tritsch, Caroline Jochems, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom, Sofia R. Gameiro   +12 more
doaj   +1 more source

Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]

, 2005
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R., Long, Carlin, McKinsey, Timothy A., Olson, Eric N.   +3 more
core   +1 more source

Design, Synthesis, and In-silico Evaluation of Benzyl oxybenzoate Derivatives as Dual HDAC Inhibitors for Cancer and CNS Disorders

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Histone deacetylase (HDAC) inhibitors have garnered attention as possible therapies for disorders affecting the central nervous system (CNS) and cancer.
Dhiaa Ali Abdulkader, Monther Faisal Mahdi   +1 more
doaj   +1 more source

Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer

Journal of Translational Medicine, 2011
Background Interleukin-13 Receptor α2 (IL-13Rα2) is a tumor-associated antigen and target for cancer therapy. Since IL-13Rα2 is heterogeneously overexpressed in a variety of human cancers, it would be highly desirable to uniformly upregulate IL-13Rα2 ...
Puri Raj K, Joshi Bharat H, Fujisawa Toshio   +2 more
doaj   +1 more source