Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi [PDF]
Frontiers in Oncology, 2018 Genetic and epigenetic changes in DNA are involved in cancer development and tumor progression. Histone deacetylases (HDACs) are key regulators of gene expression that act as transcriptional repressors by removing acetyl groups from histones.
Amila Suraweera +2 more
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Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer
Epigenetics, 2020 Histone deacetylases (HDACs) have been linked to a variety of cancers, and HDAC inhibitors (HDACi) are a promising class of drugs that have demonstrated anti-cancer effects.
Yingyan Han, Zhi Wang, Shujuan Sun
exaly +3 more sources
Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy [PDF]
Molecular Therapy: Nucleic AcidsDuchenne muscular dystrophy (DMD) is the most common inherited muscle disease. There are currently few effective therapies to treat the disease, although many approaches are being pursued. Certain histone deacetylase inhibitors (HDACi) have been shown to
Ke’ale W. Louie +8 more
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Data in Brief, 2021 Transcriptomic biomarkers facilitate mode of action analysis of toxicants by detecting specific patterns of gene expression perturbations. We identified an 81-gene transcriptomic biomarker of histone deacetylase inhibitors (HDACi) using whole ...
Eunnara Cho +2 more
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Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes [PDF]
PharmaceuticalsHistone deacetylases (HDACs) are crucial enzymes involved in the regulation of gene expression through chromatin remodeling, impacting numerous cellular processes, including cell proliferation, differentiation, and survival.
Pedro de Sena Murteira Pinheiro +4 more
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Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder [PDF]
Journal of Medicine and Life Science, 2021 The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors.
Sung-Cherl Jung +5 more
doaj +1 more source
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy
OncoImmunology, 2021 The success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and many patients relapse owing to immune escape.
Xiaolei Li, Hanren Dai, Hua Wang
doaj +1 more source
Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity
The Lancet. Healthy Longevity, 2021 Summary: Histone deacetylase inhibitors (HDACi) regulate gene expression via epigenetic mechanisms. Accumulating evidence suggests that HDACi exert antiproliferative, antioxidant, antineoplastic, and proapoptotic effects through epigenetic mechanisms ...
João Pedro Ferreira, MD +2 more
doaj +1 more source
Antioxidants, 2021 Histone deacetylase inhibitors (HDACi) are emerging as anti-hepatocellular carcinoma (HCC) agents. However, the molecular mechanisms underlying HDACi-induced sensitization to oxidative stress and cell death of HCC remain elusive.
Hae-Ahm Lee +3 more
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Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma
Cells, 2020 Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance.
Kishor Pant +3 more
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