Results 61 to 70 of about 5,372 (204)

Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad

Molecules, 2020
UV irradiation is one of the main causes of extrinsic skin aging. UV-mediated skin aging, also known as photoaging, causes excessive breakdown of extracellular matrix which leads skin to lose its elasticity and strength.
Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, So Young Park, Youngwan Seo, Chang-Suk Kong   +5 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol

BMC Complementary and Alternative Medicine, 2018
Background Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. Gamma-tocotrienol (γT3) is one of the members of vitamin E family which has been shown to increase proliferation of ...
Jen-Kit Tan, Faizul Jaafar, Suzana Makpol   +2 more
doaj   +1 more source

Targeting Mitochondria in Melanoma

Biomolecules, 2020
Drastically elevated glycolytic activity is a prominent metabolic feature of cancer cells. Until recently it was thought that tumor cells shift their entire energy production from oxidative phosphorylation (OXPHOS) to glycolysis.
Sepideh Aminzadeh-Gohari, Daniela D. Weber, Luca Catalano, René G. Feichtinger, Barbara Kofler, Roland Lang   +5 more
doaj   +1 more source

Unravelling polyphenol skin permeation: A comparative study using full‐thickness 3D in vitro and ex vivo human skin models

International Journal of Cosmetic Science, EarlyView.
This study demonstrates that full‐thickness 3D in vitro skin models reliably assess the permeation of cosmetic polyphenols, revealing compound‐specific transport profiles and bridging the gap between conventional cell models and ex vivo human skin, while offering an ethical and robust alternative for dermal absorption screening. Abstract The evaluation
Mariana Marques, Filipa Teixeira, Mónica Vieira, M. Helena Amaral, Paulo C. Costa, Stefano Dall'Acqua, Francisca Rodrigues   +6 more
wiley   +1 more source

Methods for substituting onsite ambient ultraviolet radiation measurements for personal exposure studies

Photochemistry and Photobiology, EarlyView.
Three methods for substituting on‐site ambient ultraviolet radiation measurements for personal exposure measurements were investigated. Assuming spatial persistency of measurements from high‐grade instruments delivers lowest uncertainties up to distances of 82 km.
F. Lubitz, S. Helletzgruber, H. Danhel, D. Radmanovac, A. Dzwonek, E. Kitz, P. Weihs, A. W. Schmalwieser   +7 more
wiley   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Stress-stimulated epinephrine induces premature senescence in dermal fibroblasts and contributes to impaired skin wound healing [PDF]

Brazilian Journal of Medical and Biological Research
External factors accelerate cellular senescence in the skin and compromise its repair process. Psychological stress impairs skin wound healing, but no study examined its role in cellular senescence during skin tissue repair.
J.T. da Silva, C.O.S. Meira, J.S. Nogueira, M. Lanzetti, B. Romana-Souza   +4 more
doaj   +1 more source

A Triassic chronostratigraphic and palaeogeographic framework for the Utsira High area, northern North Sea: Reconstructing a basin‐scale drainage divide

Sedimentology, EarlyView.
ABSTRACT The Triassic succession of the northern North Sea comprises a series of interbedded sandstones, mudstones and conglomerates deposited under a fluctuating arid to semi‐humid climate regime, which are often difficult to correlate regionally due to differing lithostratigraphic schemes and poor age control. Despite existing regional studies on the
Riccardo Sordi, Adrian Hartley, Shaan Heydenrych, Spyridon Saltapidas   +3 more
wiley   +1 more source