Results 131 to 140 of about 260,232 (263)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

open access: yesiNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little   +12 more
wiley   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

open access: yesiNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang   +9 more
wiley   +1 more source

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

open access: yesiNew Medicine, EarlyView.
ABSTRACT Objective The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen   +10 more
wiley   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Serum Apelin‐13 and Galectin‐3 in COVID‐19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case–Control Study

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Serum Apelin‐13 and Galectin‐3 levels were measured by ELISA in COVID‐19–positive patients and controls and evaluated alongside routine biochemical parameters. COVID‐19 patients showed significant alterations in liver, renal, inflammatory, and metabolic markers.
İsmail Uğurlu
wiley   +1 more source

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