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HDL and atherosclerosis: Insights from inherited HDL disorders
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015Plasma high density lipoproteins (HDL) comprise a highly heterogeneous family of lipoprotein particles, differing in density, size, surface charge, and lipid and protein composition. Epidemiological studies have shown that plasma HDL level inversely correlates with atherosclerotic cardiovascular disease.
L. Calabresi +4 more
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2022
In this chapter, we summarize the relationship between circulating high-density lipoprotein (HDL) and atherosclerotic cardiovascular disease (ASCVD). HDL acts in many types of cells, such as endothelial cell, macrophage, T lymphocyte, etc. Recently, novel HDL-related therapies have been developed to treat ASCVD.
Hongtu, Cui, Qian, Du
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In this chapter, we summarize the relationship between circulating high-density lipoprotein (HDL) and atherosclerotic cardiovascular disease (ASCVD). HDL acts in many types of cells, such as endothelial cell, macrophage, T lymphocyte, etc. Recently, novel HDL-related therapies have been developed to treat ASCVD.
Hongtu, Cui, Qian, Du
openaire +2 more sources
2022
In this chapter, we will focus on HDLs' activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capacity of HDL is mainly exhibited in regulation of apoA-I and alterations at the level of the HDL lipidome and the modifications of the proteome ...
Qi, Zhang, Zongzhe, Jiang, Yong, Xu
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In this chapter, we will focus on HDLs' activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capacity of HDL is mainly exhibited in regulation of apoA-I and alterations at the level of the HDL lipidome and the modifications of the proteome ...
Qi, Zhang, Zongzhe, Jiang, Yong, Xu
openaire +2 more sources
2022
In addition to the well-known functions, plasma HDL also plays an important role in postsurgery periods. In this chapter, we summarized the changes of HDL after surgery like bariatric surgery and cardiac surgery. Not only the amount of HDL changed, the HDL components or functions have also been altered after various surgeries.
Yue-Ming, Peng, Jing-Song, Ou
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In addition to the well-known functions, plasma HDL also plays an important role in postsurgery periods. In this chapter, we summarized the changes of HDL after surgery like bariatric surgery and cardiac surgery. Not only the amount of HDL changed, the HDL components or functions have also been altered after various surgeries.
Yue-Ming, Peng, Jing-Song, Ou
openaire +2 more sources
2022
In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism ...
Hongtu, Cui, Kaixuan, Lv, Nana, Yang
openaire +2 more sources
In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism ...
Hongtu, Cui, Kaixuan, Lv, Nana, Yang
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Colesterol HDL bajo o hipofunción HDL
Medicina Clínica, 2012El colesterol unido a las lipoproteinas de alta densidad (cHDL) es un excelente factor de riesgo cardiovascular en la practica totalidad de las poblaciones estudiadas hasta la actualidad. En realidad, el cHDL es el mejor predictor de riesgo lipidico junto a la concentracion de colesterol no-HDL, y la alteracion lipidica mas frecuente en sujetos que ...
Fernando Civeira, Elena Burillo
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Current Opinion in Lipidology, 2015
To summarize the current evidence concerning the role of HDL-C and HDL-associated parameters in the risk for cardiovascular disease (CVD).Numerous population studies have shown that plasma levels of HDL-C are inversely associated with CVD risk; in patient care HDL-C levels are therefore widely implemented in risk estimation models.
G Kees, Hovingh +2 more
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To summarize the current evidence concerning the role of HDL-C and HDL-associated parameters in the risk for cardiovascular disease (CVD).Numerous population studies have shown that plasma levels of HDL-C are inversely associated with CVD risk; in patient care HDL-C levels are therefore widely implemented in risk estimation models.
G Kees, Hovingh +2 more
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Current Pharmaceutical Design, 2014
High density lipoprotein cholesterol (HDL-C) and its related apolipoproteins form part of the reverse cholesterol transport system that removes excessive cholesterol from the periphery to the liver. Many transport proteins and enzymes that are involved in this process are susceptible to genetic defects that influence plasma HDL-C concentrations and HDL
Devaki R, Nair, Arun, Nair, Anjly, Jain
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High density lipoprotein cholesterol (HDL-C) and its related apolipoproteins form part of the reverse cholesterol transport system that removes excessive cholesterol from the periphery to the liver. Many transport proteins and enzymes that are involved in this process are susceptible to genetic defects that influence plasma HDL-C concentrations and HDL
Devaki R, Nair, Arun, Nair, Anjly, Jain
openaire +2 more sources
LDL and HDL Subfractions, Dysfunctional HDL: Treatment Options
Current Pharmaceutical Design, 2014Low-density lipoproteins (LDL) are considered as important risk factors for cardiovascular diseases (CVD), while highdensity lipoproteins (HDL) are well recognized for their putative role in reverse cholesterol transport and other atheroprotective functions.
Garcia-Rios, Antonio +5 more
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