Results 271 to 280 of about 428,492 (343)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Association Between Lipid-Lowering Therapy and Differences in the Distribution of LDL-C, apoB and non-HDL-C. [PDF]

J Clin Med
Ziółkowski M, Obońska K, Ratajczak J, Adamski P, Banach M, Chlebus K, Grzelakowska K, Jankowski P, Krintus M, Kryś J, Laskowska E, Mrzywka N, Niezgoda P, Ostrowska M, Podhajski P, Skonieczny G, Sosnowska B, Szarpak Ł, Topolska M, Umińska J, Rzepka-Cholasińska A, Navarese EP, Kubica J.   +22 more
europepmc   +1 more source

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, EarlyView.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression. [PDF]

Sci Rep
Deng M, Wang Z, Zhao W, Xu W, Chen S, Ma X, Song K, Li F.   +7 more
europepmc   +1 more source

Adipose Tissue in SARS‐CoV‐2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update

Obesity, EarlyView.
Adipose tissue as a potential reservoir for and modifier of SARS‐CoV‐2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infection capacity of SARS‐CoV‐2 with interplay between macrophages and adipocytes as target cells for viral tropism.
Liam Charles Maher, Paul M. Ryan, Noel M. Caplice   +2 more
wiley   +1 more source

High-density lipoprotein cholesterol and kidney disease progression in patients with type 2 diabetes mellitus: the Fukushima Cohort Study. [PDF]

BMJ Open Diabetes Res Care
Nakada K, Tanaka K, Kimura H, Saito H, Oda A, Watanabe S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ.   +9 more
europepmc   +1 more source

Addition of Phentermine‐Topiramate to a Digitally Enhanced Lifestyle Intervention: A Double‐Blind Randomized Clinical Trial

Obesity, EarlyView.
ABSTRACT Objective This study compared the effects of phentermine‐topiramate‐ER (mid‐dose 7.5/46 mg) versus placebo on weight loss and cardiovascular disease (CVD) risk outcomes when used as an adjunct to a digitally enhanced lifestyle intervention (DELI).
Alejandro Campos, Wissam Ghusn, Lizeth Cifuentes, Daniel Sacoto, Sima Fansa, Diego Anazco, Maria L. Ricardo‐Silgado, Anas Hashem, Megan Schaefer, William S. Harmsen, Heather J. Gunn, Craig Peterson, Deborah Larsen, Santosh T. Varghese, Maria D. Hurtado, Andres Acosta   +15 more
wiley   +1 more source

HDL protein composition differs between young white European and South Asian men before and after weight gain. [PDF]

Clin Sci (Lond)
Beazer JD, McLaren J, Christoffersen C, Ferraz MJ, Mulder MT, Graham D, Karlsson H, Ljunggren SA, Gill JMR, Freeman DJ.   +9 more
europepmc   +1 more source

The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study

Obesity, EarlyView.
ABSTRACT Objective We previously identified distinct muscle and liver insulin resistance (IR) metabotypes in middle‐aged and older adults. The PERSON study showed that a low‐fat, high‐protein, high‐fiber diet benefits the muscle IR group, while a high‐monounsaturated fatty acid diet benefits the liver IR group. We also developed the MetaboHealth score,
Jordi Morwani‐Mangnani, Fatih A. Bogaards, Alexander Umanets, Gabby B. Hul, Anouk Gijbels, Gijs H. Goossens, Joris Deelen, Marian Beekman, Lydia Afman, Ellen E. Blaak, P. Eline Slagboom   +10 more
wiley   +1 more source