Results 1 to 10 of about 24,460 (200)

Assessment of Human Epididymis Protein 4 Expression in Breast Ductal Carcinoma In Situ [PDF]

Diagnostics
Background/Objectives: Elevated expression of human epididymis protein 4 (HE4) has been observed in breast cancer and is associated with cancer progression; however, its role in ductal carcinoma in situ (DCIS) remains unclear.
Nah Ihm Kim, Min Ho Park, Ji Shin Lee
doaj   +2 more sources

The NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer.

PLoS ONE
Ovarian cancer is the leading cause of death among gynecologic malignancies. Despite recent advancements in targeted therapies such as PARP inhibitors, recurrence is common and frequently resistant to existing therapies.
Kyukwang Kim, Negar Khazan, Jamie L McDowell, Cameron W A Snyder, John P Miller, Rakesh K Singh, Michelle E Whittum, Rachael Turner, Richard G Moore   +8 more
doaj   +4 more sources

Diagnostic value of CEACAM6 and HE4 in pleural fluid for malignant pleural effusion [PDF]

Annals of Medicine
Objective This study aimed to assess the diagnostic performance of carcinoembryonic antigen-related adhesion molecule 6 (CEACAM6) and human epididymis protein 4 (HE4) in pleural fluid for the detection of malignant pleural effusion (MPE).Materials and ...
Jie Li, Liyuan Lin, Shengrui Yang, Yuan Mu, Lixia Zhang, Haoyu Ruan, Jian Xu   +6 more
doaj   +2 more sources

Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic inflammation and airway remodeling. Human epididymis protein 4 (HE4) plays a critical role in various inflammatory or fibrotic diseases.
Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng, Jungang Xie   +10 more
doaj   +1 more source

Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis

RMD Open, 2022
Objectives IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder with heterogeneous manifestations. This study aimed to investigate the utility of human epididymis protein 4 (HE4) as a potential clinical biomarker of fibrosis in
Wen Zhang, Yongzhe Li, Yuan Huang, Songxin Yan, Yu Peng, Hui Lu, Ziyan Wu, Shengwei Mo, Xianlong Chen, Xiaomeng Li   +9 more
doaj   +1 more source

Serum Human Epididymis Protein 4 as a Novel Biomarker in Identifying Patients With Interstitial Lung Disease in Rheumatoid Arthritis

Frontiers in Medicine, 2021
Objective: Human epididymis protein 4 (HE4) have been implicated in the pulmonary involvements. We aimed to investigate the clinical utility of HE4 in clinical stratification in patients with rheumatoid arthritis (RA).Methods: This study included a ...
Liu Liang, Liu Liang, Jiali Chen, Chun Di, Minghua Zhan, Huizhang Bao, Changsheng Xia, Chunhong Fan, Yudong Liu   +8 more
doaj   +1 more source

Evaluation of follow-up observation using human epididymis protein 4, a tumor marker, in patients with ovarian cancer [PDF]

Obstetrics & Gynecology Science, 2023
Objective We evaluated the usefulness of human epididymis protein 4 (HE4), a tumor marker, during and after treatment in patients with ovarian cancer (OC).
Masaya Uno, Rie Matsuo, Naoki Maezawa, Tomoyasu Kato   +3 more
doaj   +1 more source

MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension

Cardiovascular Therapeutics, 2022
Background. Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. But cardiac fibrosis mechanism remains unclear.
Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian   +8 more
doaj   +1 more source

HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is a secretory protein expressed in activated fibroblasts that exacerbates tissue fibrosis.
Masahiro Yamamoto, Shinsuke Hanatani, Satoshi Araki, Yasuhiro Izumiya, Toshihiro Yamada, Nobuhiro Nakanishi, Toshifumi Ishida, Satoru Yamamura, Yuichi Kimura, Yuichiro Arima, Taishi Nakamura, Seiji Takashio, Eiichiro Yamamoto, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Sachio Morimoto, Takaaki Ito, Kenichi Tsujita   +18 more
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Role of HE4 and ROMA Score in Diagnosis of Ovarian Cancer in Egyptian Women [PDF]

Middle East Journal of Cancer, 2021
Background: Risk of ovarian malignancy algorithm (ROMA) combining human epididymis secretory protein 4 (HE4) and CA125 is a novel score, specific for epithelial ovarian cancer (EOC).
Nahla El-Attar, Lamiaa Kamel, Amany Abdelghany, Rasha Haggag, Heba Taha, Entesar Mahdy, Nadia Madkour   +6 more
doaj   +1 more source