Results 61 to 70 of about 59,376 (244)
Skip metastasis in papillary thyroid carcinoma is difficult to predict in clinical practice
BMC Cancer, 2017 Background Cervical lymph node metastases are very common in papillary thyroid cancer (PTC), and typically spread in a predictable stepwise fashion in clinical practice. However, lateral lymph node metastasis (LLNM) without central lymph node metastasis (
Xilin Nie, Zhou Tan, Minghua Ge
doaj +1 more source
Molecular Cancer, 2021 The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRISPR/Cas9) gene editing technology that ...
Huimin Zhang +11 more
doaj +1 more source
Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
Laryngoscope Investigative Otolaryngology, 2020 Background Head and neck squamous cell carcinoma (HNSCC) has been rising in incidence primarily related to HPV‐associated oropharyngeal cancers. Novel molecular therapeutics are evolving with the mTOR pathway as a new target.
Jaimin Patel +5 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi‐quantitative MRI measure sensitive to MS‐related tissue microstructural changes, in the cSC and its ...
Lisa Eunyoung Lee +26 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.A 3D bioprinted HNSCC model for use in anti‐cancer drug testing is established in proof‐of‐concept. The innovative tunicate‐derived nanocellulose hydrogel proved to be a viable alternative to gelatin‐based hydrogel, offering improved bioprintability for HNSCC model establishment.
Alexya Azhakesan +7 more
wiley +1 more source
International Journal of Endocrinology, 2019 Background. Anaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach to manage. The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate ...
Nai-si Huang +8 more
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Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva
BMC Cancer, 2019 Background There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status.
Wei Du +4 more
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