Results 51 to 60 of about 226,619 (252)

ORAL PAPILLARY SQUAMOUS CELL CARCINOMA: CASE REPORT AND LITERATURE REVIEW

Revista Naval de Odontologia On Line, 2021
Papillary squamous cell carcinoma is a tumor that affects the upper aerodigestive tract, but rarely the oral cavity. The aim of this study is to report a case of oral papillary squamous cell carcinoma and to review the available literature. We
Lísia Daltro Borges Alves, Alessandra Laís Pinho Valente Pires, Tarsila de Carvalho Freitas Ramos, Márcio Campos Oliveira, Valéria Souza Freitas   +4 more
doaj   +1 more source

A Review of Photodynamic Therapy for Neoplasms of the Head and Neck

Advances in Therapy, 2018
Photodynamic therapy (PDT) involves the use of a phototoxic drug which is activated by low powered laser light to destroy neoplastic cells. Multiple photosensitizers have been studied and tumors have been treated in a variety of head and neck sites over the last 30 years.
Francisco J. Civantos, Barış Karakullukcu, Merrill Biel, Carl E. Silver, Alessandra Rinaldo, Nabil F. Saba, Robert P. Takes, Vincent Vander Poorten, Alfio Ferlito   +8 more
openaire   +5 more sources

HYDROXYUREA: A RADIOSENSITIZER IN THE TREATMENT OF NEOPLASMS OF THE HEAD AND NECK [PDF]

American Journal of Roentgenology, 1969
Forty patients were treated in a double blind study utilizing Hydroxyurea. Those treated with Hydroxyurea, irradiation and surgery achieved complete eradication of tumor.The most notable contribution of Hydroxyurea appeared to be the extensive necrosis, radiation effect, and destruction beyond any recognition of tumor in lymph nodes.Forty-five cases ...
Robert G. Chambers, George J. Richards
openaire   +3 more sources

Prognostic significance of serine-phosphorylated STAT3 expression in pT1-T2 oral tongue carcinoma [PDF]

, 2015
Objectives. Phosphorylated (activated) STAT3 (pSTAT3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion ...
Cappellesso, R, DE FILIPPIS, Cosimo, Fasanaro, E, Giacomelli, L, Marino, F, Marioni, Gino, Ottaviano, Giancarlo, Staffieri, Alberto, Staffieri, C, Stellini, Edoardo, Val, M   +10 more
core   +3 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Dermoscopic and clinical features of head and neck melanoma [PDF]

Anais Brasileiros de Dermatologia, 2015
BACKGROUND:The dermoscopic criteria of extrafacial melanomas are well-known.OBJECTIVE:To determine the frequency of dermatoscopic findings in head and neck melanomas (HNM) and to assess the distinguishing dermoscopic criteria of facial and extrafacial ...
Fatma Pelin Cengiz, Abdurrahman Bugra Cengiz, Nazan Emiroglu, Ela Comert, Rainer Hofmann Wellenhof   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Primary Concurrent Chemoradiation in Head and Neck Cancers with Weekly Cisplatin Chemotherapy: Analysis of Compliance, Toxicity and Survival

International Archives of Otorhinolaryngology, 2017
Introduction Concurrent chemoradiation is the standard of care in inoperable locally advanced squamous cell head and neck cancers. The most widely accepted schedule of concomitant cisplatin is 100mg/m2 given on a 3 weekly basis but the optimal regime is ...
Muhammad Shahid Iqbal, Cheng Chaw, Josef Kovarik, Shahzeena Aslam, Aaron Jackson, John Kelly, Werner Dobrowsky, Charles Kelly   +7 more
doaj   +1 more source

Risk of critical illness among patients with solid cancers: a population-based observational study of 118,541 adults [PDF]

, 2015
Importance: Critical illness may be a potential determinant of cancer outcomes and geographic variations, but its role has not been described before. Objective: To determine the incidence of admission to intensive care units (ICUs) within 2 years ...
Kinsella, John, McLoone, Philip, Morrison, David S., Puxty, Kathryn, Quasim, Tara, Sloan, Billy   +5 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source