Results 51 to 60 of about 53,166 (277)

Challenges and Needs for Support in Managing Occupational Health and Safety from Managers’ Viewpoints

open access: yesNordic Journal of Working Life Studies, 2014
Proper working conditions and successful occupational health and safety (OHS) management help organizations achieve their targets and support the quality of working life and performance.
Sari Tappura   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Untimely Welfare Technologies

open access: yesNordic Journal of Working Life Studies, 2019
Welfare technologies are introduced to increase the quality and efficiency of the delivery of welfare services, due to its ‘time-saving’ capacities.This study will examine that even though this might be the case, new technologies such as electronic ...
Anders la Cour, Holger Højlund
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

What works? A review of actions addressing the social and economic determinants of Indigenous health [PDF]

open access: yes, 2013
Introduction: The purpose of this paper is to review evidence relating to ‘what works’ to influence the social and economic determinants of Indigenous health, in order to reduce health inequities, and ultimately contribute to closing the life expectancy ...
Lynsey Brown, Katy Osborne, Fran Baum
core  

Sorting Out Agencies in AI-supported Radiological Work Practices

open access: yesNordic Journal of Working Life Studies
The article examines how narrow-task artificial intelligence (NT-AI) implementation reconfigures professional practice and agency in radiology departments.
Astrid Galsgaard, Anders Buch
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Health and wellbeing in design studio briefs – Architecture and engineering graduating students’ motivations and approaches

open access: yes, 2020
© The Author(s) 2020. The purpose of this paper is to reflect upon architecture and environmental engineering students’ approaches to health and wellbeing issues in design studio project briefs.
Cash, Dan   +3 more
core   +1 more source

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