Results 61 to 70 of about 20,327,512 (268)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Remote Work and the Psychosocial Work Environment: The Role of Contact
Nordic Journal of Working Life StudiesRemote work is fundamentally changing the organization of work, replacing the physical work environment of the office and creating a spatial distance between colleagues.
Mari Holm Ingelsrud +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Working across health services and academia: challenges and solutions for health research [PDF]
, 2019 This report presents the proceedings of an Irish Health Research Forum event held on November 13th 2019 on the challenges and potential solutions for researchers working across health services and academia. It also makes key recommendations for improving
Health Research Charities Ireland
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Strategy for Doctors’ Health and Wellbeing 2018 - 2021
, 2018 The primary purpose of The Strategy for Doctors’ Health and Wellbeing 2018-2021 is to provide standards to safeguard and improve the health and wellbeing of doctors. The intended audience includes doctors and medical students, employers, medical schools,
The Workplace Health and Wellbeing Unit
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, 2017 Wellbeing – or the prudential good life – refers to how well someone’s life is going for him or her (Crisp, 2014 ). Increasingly, awareness of the limitations of traditional economic indicators has led researchers to call for scientifi c measures of ...
Weijers, Dan M., Jarden, Aaron
core +1 more source
Attending Weak Signals: The Prevention of Work-related Illnesses
Nordic Journal of Working Life Studies, 2017 This article examines the characteristics of communication among managers, human resource (HR) experts, and occupational health care specialists, as they deal with such informal information as weak signals in the prevention of work-related illnesses ...
Roy Liff +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Focusing resource allocation-wellbeing as a tool for prioritizing interventions for communities at risk [PDF]
, 2013 Objective: This study examined whether a wellbeing approach to resilience and adaptation would provide practical insights for prioritizing support to communities experiencing environmental and socio-economic stressors. Methods: A cross-sectional survey,
Anthony Hogan
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