Results 71 to 80 of about 1,783,278 (389)

Three Nontraditional Approaches to Improving the Capacity, Accessibility, and Quality of Mental Health Services: An Overview.

Psychiatric Services, 2018
To provide evidence for wider use of peer workers and other nonprofessionals, the authors examined three approaches to mental health service provision-peer support worker (PSW) programs, task shifting, and mental health first-aid and community advocacy ...
K. Grant, M. Simmons, C. Davey
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Acessibilidade aos serviços de saúde: uma análise a partir da Atenção Básica em Pernambuco

Saúde em Debate
Analisou-se a acessibilidade aos serviços de saúde de Atenção Básica em Pernambuco e os aspectos que favorecem ou dificultam a entrada e a permanência do usuário no sistema de saúde.
Maria do Socorro Veloso de Albuquerque, Tereza Maciel Lyra, Sidney Feitoza Farias, Marina Ferreira de Medeiros Mendes, Petrônio José de Lima Martelli   +4 more
doaj   +1 more source

Reproductive health practices and use of health services among immigrant Indonesian women working in Malaysia

Revista de Saúde Pública, 2022
OBJECTIVE To describe the reproductive health practices of immigrant Indonesian women working in Malaysia and their accessibility to health services. METHODS A cross-sectional study using a validated self-administered questionnaire was conducted with ...
Rosnah Sutan, Pinta Pudiyanti Siregar
doaj   +1 more source

Listen up: Reflections on the CDI and HSE Speech and Language Services in Tallaght West [PDF]

, 2016
The primary aim of this study was to build on the previous evaluation of the Childhood Development's Initiatives (CDI) speech and language approach and carry out a comparative evaluation of speech and language therapy services for young children across ...
Judy Irwin, Nóirín Hayes
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Dynamic geographical accessibility assessments to improve health equity: protocol for a test case in Cali, Colombia [version 1; peer review: 2 approved]

F1000Research, 2022
This protocol proposes an approach to assessing the place of residence as a spatial determinant of health in cities where traffic congestion might impact health services accessibility.
Lyda Osorio, Pablo Zapata, Luis Fernando Pinilla, María Olga Bula, Eliana Martínez-Herrera, Janet Hatcher-Roberts, Ciro Jaramillo, Daniel Cuervo, Luis Gabriel Cuervo, Carmen Juliana Villamizar, Felipe Piquero Villegas, Maria Beatriz Ospina   +11 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Location-Allocation and Accessibility Models for Improving the Spatial Planning of Public Health Services

PLoS ONE, 2015
This study integrated accessibility and location-allocation models in geographic information systems as a proposed strategy to improve the spatial planning of public health services.
Gina Polo, C. M. Acosta, F. Ferreira, Ricardo Augusto Dias   +3 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source