Results 91 to 100 of about 2,763,321 (346)

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT) [PDF]

, 2020
Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist ...
Boyers, D, Breeman, S, Cooper, K G, Elders, A, Freeman, R M, Glazener, CMA, Hagen, S, Hemming, C, Kilonzo, M, MacLennan, G, McDonald, A, McPherson, G, Montgomery, I, Norrie, J, PROSPECT study group, Reid, F M, Smith, ARB   +16 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Health technology assessment [PDF]

Clinical Governance: An International Journal, 2010
Giuseppe Turchetti, Enza Spadoni, Eliezer Geisler   +2 more
  +5 more sources

Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines

BMC Health Services Research, 2020
Background The World Health Organization (WHO) recommends oxytocin as the drug of choice for postpartum hemorrhage (PPH) prevention. However, the WHO has also recently considered carbetocin for PPH prevention, but only if carbetocin were a cost-effective
Jamaica Roanne Briones, Pattarawalai Talungchit, Montarat Thavorncharoensap, Usa Chaikledkaew   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Health Technology Assessment

Controlling, 2021
Um komplexe Entscheidungen im Gesundheitsbereich zu treffen, werden zunehmend Methoden wie die Kosten-Nutzwert-Analyse eingesetzt. Dabei werden die Kosten einer medizinischen Maßnahme dem durch sie generierten Nutzen, oft in der Form von qualitätskorrigierten Lebensjahren (QALYs), gegenübergestellt.
openaire   +2 more sources

Cost-effectiveness of HBV and HCV screening strategies:a systematic review of existing modelling techniques [PDF]

, 2015
Introduction: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling ...
A Tramarin, AA Honeycutt, AG Mulley, AH Miners, AJ Sutton, AJ Sutton, AT Urbanus, BA Plunkett, BP Linas, BR Schackman, BS Bloom, C Rossi, Claudia Geue, Coon J Thompson, David Goldberg, DB Rein, DB Rein, DW Hutton, E Castelnuovo, Elisabeth Fenwick, F Antonanzas, G Sroczynski, G Tormans, IK Veldhuijzen, IL Thomas, J Glanville, J Nakamura, JA Arevalo, JF Jusot, K Stein, K Stein, KL Lapane, LE Cipriano, LJ McGarry, M Ruggeri, M Ruggeri, ME Singer, MF Drummond, MH Eckman, MH Eckman, Natasha K. Martin, Olivia Wu, P Leal, P Zurn, PO Coffin, Robert Heggie, RP Walensky, S Deuffic-Burban, S Liu, S Loubiere, S Loubiere, S-Y Kim, Sharon Hutchinson, SJ Hahne, TS Kwan-Gett, V Josset, Vincent Wong, WW Wong, WWL Wong, Yiqiao Xin, Z Philips   +60 more
core   +5 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Advancing evidence-based decision-making in Bhutan: development of a health technology assessment framework

The Lancet Regional Health - Southeast Asia
Summary: Bhutan is currently transforming its health system and has updated its Health Technology Assessment (HTA) framework. This revision is designed to prioritize health initiatives and ensure the sustainability of the health system.
Annapoorna Prakash, Pempa, Tshering Duba, K C Sarin, Saudamini Vishwanath Dabak, Ugyen Tashi   +5 more
doaj   +1 more source

Effectiveness, benefit harm and cost effectiveness of colorectal cancer screening in Austria

BMC Gastroenterology, 2019
Background Clear evidence on the benefit-harm balance and cost effectiveness of population-based screening for colorectal cancer (CRC) is missing. We aim to systematically evaluate the long-term effectiveness, harms and cost effectiveness of different ...
Beate Jahn, Gaby Sroczynski, Marvin Bundo, Nikolai Mühlberger, Sibylle Puntscher, Jovan Todorovic, Ursula Rochau, Willi Oberaigner, Hendrik Koffijberg, Timo Fischer, Irmgard Schiller-Fruehwirth, Dietmar Öfner, Friedrich Renner, Michael Jonas, Monika Hackl, Monika Ferlitsch, Uwe Siebert, on behalf of the Austrian Colorectal Cancer Screening Model Group   +17 more
doaj   +1 more source