Results 21 to 30 of about 87,473 (267)

Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes

Translational Psychiatry, 2021
Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer’s disease. This study explores a battery of plasma lipids that can differentiate Alzheimer’s disease (AD) patients from healthy controls and determines whether lipid ...
Yue Liu, Anbupalam Thalamuthu, Karen A. Mather, John Crawford, Marina Ulanova, Matthew Wai Kin Wong, Russell Pickford, Perminder S. Sachdev, Nady Braidy   +8 more
doaj   +1 more source

Heterogeneity in Healthy Aging [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
For a surprisingly large segment of the older population, chronological age is not a relevant marker for understanding, measuring, or experiencing healthy aging. Using the 2003 Medical Expenditure Panel Survey and the 2004 Health and Retirement Study to examine the proportion of Americans exhibiting five markers of health and the variation in health ...
David J, Lowsky, S Jay, Olshansky, Jay, Bhattacharya, Dana P, Goldman   +3 more
openaire   +2 more sources

Genome‐wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

Molecular Systems Biology, 2011
FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan.
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge   +9 more
doaj   +1 more source

A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

npj Aging and Mechanisms of Disease, 2018
Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation.
Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F. Gilliat, Josephine Hellberg, Ziyu Ren, Evgeniy R. Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J. Telford, Colin T. Dolphin, Zhizhou Zhang, David Gems   +13 more
doaj   +1 more source

Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

BMC Geriatrics, 2018
Background Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging.
Elizaveta Fife, Joanna Kostka, Łukasz Kroc, Agnieszka Guligowska, Małgorzata Pigłowska, Bartłomiej Sołtysik, Agnieszka Kaufman-Szymczyk, Krystyna Fabianowska-Majewska, Tomasz Kostka   +8 more
doaj   +1 more source

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

BMC Biology, 2020
Background The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse ...
Nathaniel S. Woodling, Arjunan Rajasingam, Lucy J. Minkley, Alberto Rizzo, Linda Partridge   +4 more
doaj   +1 more source

Improving Electronic Health Record (EHR) data linkages for identifying Aged Care Residents through publicly available data

International Journal of Population Data Science
Introduction Accurate identification of Aged Care residents accessing hospital services is challenging due to multiple hospital Electronic Health Record (EHR) systems and entry points resulting in inconsistent addresses and coding.
Tanya Ravipati, Richard Beare, Velandai Srikanth, Alison Carver, Lei Huang, Rashwinder Dhillon, Nadine E Andrew   +6 more
doaj   +1 more source

Fall awareness behaviour and its associated factors among community dwelling older adults

BMC Geriatrics, 2021
Background Falls are one of the major causes of mortality and morbidity in older adults. However, despite adoption of prevention strategies, the number of falls in older adults has not declined.
Jing Wen Goh, Devinder Kaur Ajit Singh, Normala Mesbah, Anis Afifa Mohd Hanafi, Adlyn Farhana Azwan   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Hospital Electronic Health Records as a research resource: data linkage, national scale-up, and five-year Impact of the National Centre for Healthy Ageing Data Platform.

International Journal of Population Data Science
Background Established in 2020, the National Centre for Healthy Ageing (NCHA) Data Platform is Australia’s first linked hospital-based electronic health record (EHR) research database covering all residents within a geographic region.
Nadine Andrew, Richard Beare, Emily Mann, Sumit Parikh, Alison Carver, Taya Collyer, David Ung, Rashwinder Dhillon, Velandai Srikanth   +8 more
doaj   +1 more source