Results 31 to 40 of about 339,619 (303)

Ageing makes us dyslexic [PDF]

, 2013
Background: The effects of typical ageing on spoken language are well known: word production is disproportionately affected while syntactic processing is relatively well preserved.
Harley, Trevor A., Jessiman, Lesley J., MacAndrew, Siobhan B. G., Oliver, Tracey M.   +3 more
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Genome‐wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

Molecular Systems Biology, 2011
FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan.
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge   +9 more
doaj   +1 more source

Healthy Aging as Disease? [PDF]

Frontiers in Aging Neuroscience, 2011
In the scientific and popular literature recently there has been a widespread call for classifying normal aging as a disease, a condition that can be “manipulated, treated, and delayed” (Gems, 2010; Kelland, 2010). The main argument given by supporters of this suggestion is that grant-awarding bodies would be more likely to fund research into how, when,
openaire   +3 more sources

A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

npj Aging and Mechanisms of Disease, 2018
Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation.
Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F. Gilliat, Josephine Hellberg, Ziyu Ren, Evgeniy R. Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J. Telford, Colin T. Dolphin, Zhizhou Zhang, David Gems   +13 more
doaj   +1 more source

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

BMC Biology, 2020
Background The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse ...
Nathaniel S. Woodling, Arjunan Rajasingam, Lucy J. Minkley, Alberto Rizzo, Linda Partridge   +4 more
doaj   +1 more source

Fall awareness behaviour and its associated factors among community dwelling older adults

BMC Geriatrics, 2021
Background Falls are one of the major causes of mortality and morbidity in older adults. However, despite adoption of prevention strategies, the number of falls in older adults has not declined.
Jing Wen Goh, Devinder Kaur Ajit Singh, Normala Mesbah, Anis Afifa Mohd Hanafi, Adlyn Farhana Azwan   +4 more
doaj   +1 more source

Cardiovascular disease and healthy ageing [PDF]

, 2015
Cardiovascular diseases are main cause of morbidity and mortality in the Western World. Cardiovascular disease increases in its prevalence with age and the burden of this condition is set to increase with an Ageing global population.
Mc Auley, Mark T., Mooney, Kathleen M.
core   +3 more sources

Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

BMC Geriatrics, 2018
Background Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging.
Elizaveta Fife, Joanna Kostka, Łukasz Kroc, Agnieszka Guligowska, Małgorzata Pigłowska, Bartłomiej Sołtysik, Agnieszka Kaufman-Szymczyk, Krystyna Fabianowska-Majewska, Tomasz Kostka   +8 more
doaj   +1 more source

Determinants Of Healthy Ageing For Older People In European Countries – A Spatio-Temporal Approach [PDF]

, 2016
The article aims to investigate the relationship between the length of the further life in healthy for men and women aged 65 years and selected factors in European countries in the period 2005-2012.
Suchecka, Jadwiga, Urbaniak, Bogusława
core   +2 more sources

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
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