Results 21 to 30 of about 933,857 (297)

Skeletal endocrinology: where evolutionary advantage meets disease

open access: yesBone Research, 2021
The regulation of whole-body homeostasis by the skeleton is mediated by its capacity to secrete endocrine signaling molecules. Although bone-derived hormones confer several adaptive benefits, their physiological functions also involve trade-offs, thus ...
Nikolai Jaschke   +4 more
doaj   +1 more source

Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study [PDF]

open access: yes, 2014
Introduction: Excess aldosterone is associated with increased cardiovascular risk. Aldosterone has a permissive effect on vascular fibrosis. Cardiovascular magnetic resonance imaging (CMR) allows study of vascular function by measuring aortic ...
A McCurley   +40 more
core   +1 more source

Brain Age from the Electroencephalogram of Sleep [PDF]

open access: yes, 2018
The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process.
Akeju, Oluwaseun   +10 more
core   +3 more sources

Spatial and temporal aspects of visual backward masking in children and young adolescents [PDF]

open access: yes, 2016
We thank Marc Repnow for his help setting up the experiments. In addition, we thank two anonymous reviewers for their very thoughtful and helpful comments.
Herzog, Michael H.   +3 more
core   +2 more sources

Functional dedifferentiation of associative resting state networks in older adults – A longitudinal study

open access: yesNeuroImage, 2020
Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger functional interaction between these networks.
Brigitta Malagurski   +4 more
doaj   +1 more source

Disconnected aging: cerebral white matter integrity and age-related differences in cognition. [PDF]

open access: yes, 2014
Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction.
Bennett, IJ, Madden, DJ
core   +1 more source

Object-Location Memory Training in Older Adults Leads to Greater Deactivation of the Dorsal Default Mode Network

open access: yesFrontiers in Human Neuroscience, 2021
Substantial evidence indicates that cognitive training can be efficacious for older adults, but findings regarding training-related brain plasticity have been mixed and vary depending on the imaging modality.
Ania Mikos   +5 more
doaj   +1 more source

Healthy Aging as Disease? [PDF]

open access: yesFrontiers in Aging Neuroscience, 2011
In the scientific and popular literature recently there has been a widespread call for classifying normal aging as a disease, a condition that can be “manipulated, treated, and delayed” (Gems, 2010; Kelland, 2010). The main argument given by supporters of this suggestion is that grant-awarding bodies would be more likely to fund research into how, when,
openaire   +3 more sources

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

open access: yesMolecules, 2018
Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer.
Lu-Min Shih   +5 more
doaj   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

open access: yes, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles   +4 more
core   +1 more source

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