Results 31 to 40 of about 933,857 (297)

Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

JBMR Plus, 2020
Low bone strength in overweight individuals is a significant medical problem. One important determinant of mesenchymal stem cell fate into osteoblasts or adipocytes is the Wnt signaling pathway.
Juliane Colditz, Ann‐Kristin Picke, Lorenz C. Hofbauer, Martina Rauner   +3 more
doaj   +1 more source

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

Frontiers in Physiology, 2017
Introduction/Purpose: A number of studies have investigated the effect of training with a moderate exercise dose (3–6 h/weekly) on the inflammatory profile in blood, and the data are inconsistent.
Ronni E. Sahl, Peter R. Andersen, Katja Gronbaek, Thomas H. Morville, Mads Rosenkilde, Hanne K. Rasmusen, Steen S. Poulsen, Clara Prats, Flemming Dela, Flemming Dela, Jørn W. Helge   +10 more
doaj   +1 more source

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

Cell Death and Disease, 2022
Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and
Lin Zhao, Yuanyuan Liu, Simiao Zhang, Lingyu Wei, Hongbing Cheng, Jinsheng Wang, Jia Wang   +6 more
doaj   +1 more source

Age and diabetes related changes of the retinal capillaries: an ultrastructural and immunohistochemical study [PDF]

, 2015
Normal human aging and diabetes are associated with a gradual decrease of cerebral flow in the brain with changes in vascular architecture. Thickening of the capillary basement membrane and microvascular fibrosis are evident in the central nervous system
ARTICO, Marco, BATTAGLIONE, Ezio, BIANCHI, ENRICA, Feher, Janos, Kovacs, Illes, MAGLIULO, Giuseppe, Micera, Alessandra, ORLANDO, Maria Patrizia, PLATEROTI, Rocco, Ripandelli, Guido, TAURONE, SAMANTA   +10 more
core   +1 more source

7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells

Cells, 2021
7-Ketocholesterol (7KCh) is a major oxidized cholesterol product abundant in lipoprotein deposits and atherosclerotic plaques. Our previous study has shown that 7KCh accumulates in erythrocytes of heart failure patients, and further investigation ...
Mei-Ling Cheng, Hsiang-Yu Tang, Pei-Ting Wu, Cheng-Hung Yang, Chi-Jen Lo, Jui-Fen Lin, Hung-Yao Ho   +6 more
doaj   +1 more source

Calcium Binding Mechanism of Soybean Peptide with Histidine Alteration by Molecular Docking Analysis and Spectroscopic Methods

Foods, 2022
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays an irreplaceable role in peptides and proteins. With the current study, we aimed to determine the characteristics and functional activities of the bone density of soy peptide ...
Jing Gan, Xiao Kong, Ziqun Xiao, Yuhang Chen, Mengdi Du, Yan Wang, Zhenhua Wang, Yongqiang Cheng, Bo Xu   +8 more
doaj   +1 more source

I'm an international student. My name is Sean. I hate being called "Sean" and I hate that I have to speak in an accent. [PDF]

, 2018
1_sm64ucz
Healthy Aging Lab
core  

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]

, 2016
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson, Anisimov, Atarashi, Augustine, Bates, Blackwell, Chen, Dai, de Oliveira, Ericsson, Ericsson, Flynn, Goldman, Halloran, Hard, Harrison, Hothorn, Johnson, Johnson, Johnson, Kaeberlein, Lamming, Majumder, Mannick, Mathew, Miller, Miller, Paulson, Prakash, Ramos, Treuting, Wilkinson, Xu, Zhang   +33 more
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Chronic loneliness and longitudinal changes in cognitive functioning

BMC Public Health
Background Loneliness is a worldwide concern with significant health implications that may be a significant risk factor for Alzheimer’s disease and related dementias.
Jee eun Kang, Lynn M. Martire, Jennifer E. Graham-Engeland, David E. Almeida, Martin J. Sliwinski   +4 more
doaj   +1 more source