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Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms
Advanced Healthcare Materials, 2023AbstractCardiovascular disease is a major cause of mortality worldwide, and current preclinical models including traditional animal models and 2D cell culture models have limitations in replicating human native heart physiology and response to drugs.
Xinyi Chen +8 more
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Bioinspired optical and electrical dual-responsive heart-on-a-chip for hormone testing
Science Bulletin, 2023Heart-on-chips have emerged as a powerful tool to promote the paradigm innovation in cardiac pathological research and drug development. Attempts are focused on improving microphysiological visuals, enhancing bionic characteristics, as well as expanding their biomedical applications.
Feika Bian, Yuan Jin Zhao, Lingyu Sun
exaly +3 more sources
2017
Heart diseases are the most common cause of death around the world. Therefore, it is important to develop new drugs and therapies, which can be useful in the treatment of cardiovascular diseases (CVDs). Elaboration of in vivo-like culture models of heart cells will allow the mimicking of native heart tissue and the investigation of heart cell response ...
Magdalena Bulka, Elzbieta Jastrzebska
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Heart diseases are the most common cause of death around the world. Therefore, it is important to develop new drugs and therapies, which can be useful in the treatment of cardiovascular diseases (CVDs). Elaboration of in vivo-like culture models of heart cells will allow the mimicking of native heart tissue and the investigation of heart cell response ...
Magdalena Bulka, Elzbieta Jastrzebska
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Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip [PDF]
Biomaterials, 2016 Engineering cardiac tissues and organ models remains a great challenge due to the hierarchical structure of the native myocardium. The need of integrating blood vessels brings additional complexity, limiting the available approaches that are suitable to produce integrated cardiovascular organoids.
Danilo Demarchi +2 more
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Generation of functional cardiac microtissues in a beating heart-on-a-chip
2018With the increasing attention on cardiovascular disorders and the current inability of pre-clinical models to accurately predict human physiology, the need for advanced and reliable heart in vitro models is paramount. Microfabrication technologies provide potential solutions in the organs-on-chip systems: microengineered devices where cell cultures can
Ugolini, Giovanni Stefano +4 more
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A micropower analog-digital heart rate detector chip
Analog Integrated Circuits and Signal Processing, 1994A micropower detector chip integrated with CMOS technology has been developed for a hand-held heart rate monitoring instrument mainly used by professional athletes and others who exercise seriously to increase their endurance and overall performance. The chip uses linear bandpass filtering and threshold detection and is implemented with analog switched-
Antti Ruha +2 more
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Heart-on-a-chip systems: disease modeling and drug screening applications
Lab on a ChipHeart-on-chip systems are one of the tools at the forefront in the race to develop alternative in vitro preclinical testing for disease modeling, drug toxicity and efficacy assessment. Further innovation and standardization will accelerate their use.
Derrick Butler, Darwin R. Reyes
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Photonic crystal colorimetric sensing in heart-on-a-chip systems
Current Opinion in Biomedical EngineeringFeika Bian, Yuan Jin Zhao, Lingyu Sun
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Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease
Nature Reviews CardiologyOrgan-on-a-chip platforms have revolutionized the modelling of cardiovascular pathophysiology, enabling researchers to elucidate underlying mechanisms and drug responses for a variety of inherited and acquired diseases. This emerging technology can overcome the limitations of traditional in vitro culture systems and animal models such as poor ...
Ramak Khosravi, Milica Radisic
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