Results 51 to 60 of about 132,211,819 (268)
Correction: 3D printed nervous system on a chip
, 2016 Correction for ‘3D printed nervous system on a chip’ by Blake N.
Meng, Fanben +6 more
core +1 more source
Frontiers in Bioengineering and BiotechnologyElectrospun nanofibers have emerged as a promising platform for cardiac tissue engineering, offering unique opportunities to recapitulate the native myocardial extracellular matrix (ECM) architecture.
Raminta Vaiciuleviciute +9 more
doaj +1 more source
Integrated Nano Liquid Chromatography System On-a-Chip [PDF]
, 2006 Integrated liquid chromatography (LC) chips are valued because of their significant advantages over conventional systems. However, they are very challenging to build due to the high complexity of LC systems and the need for high-level integration of many
He, Qing
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Dataset for transcriptomic, H3K9ac and H3K9me3 profiles during cardiac regeneration
Data in Brief, 2022 Acetylation and tri-methylation of histone H3 lysine 9 (H3K9ac and H3K9me3) play an interactive regulatory role in the epigenetic regulation of gene expression during heart development and cardiovascular disease, but little is known about their possible ...
Xuelong Wang +7 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips
Micromachines, 2019 Organ-on-chip (OOC) is becoming the alternative tool to conventional in vitro screening. Heart-on-chip devices including microstructures for mechanical and electrical stimulation have been demonstrated to be advantageous to study structural organization ...
William F. Quirós-Solano +5 more
doaj +1 more source
Liver–Heart on chip models for drug safety
APL Bioengineering, 2021 Current pre-clinical models to evaluate drug safety during the drug development process (DDP) mainly rely on traditional two-dimensional cell cultures, considered too simplistic and often ineffective, or animal experimentations, which are costly, time ...
Erika Ferrari, Marco Rasponi
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Studying Epigenetics of Cardiovascular Diseases on Chip Guide
Cardiogenetics, 2022 Epigenetics is defined as the study of inheritable changes in the gene expressions and phenotypes that occurs without altering the normal DNA sequence.
Bandar Ali Alghamdi +6 more
doaj +1 more source