Results 91 to 100 of about 1,271,305 (362)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Incorporating Inductances in Tissue-Scale Models of Cardiac Electrophysiology [PDF]

, 2017
In standard models of cardiac electrophysiology, including the bidomain and monodomain models, local perturbations can propagate at infinite speed.
Balay S., Benson A. P., Boyce E. Griffith, Cattaneo C., Colli Franzone P., DeHaan R. L., Fastl T. E., Jou D., Keener J. P., Krueger M. W., MATLAB, Neu J. C., Sachse F. B., Simone Rossi, ten Tusscher K. H. W. J., Thomas C. E., Tung L., Wikswo J. P.   +17 more
core   +3 more sources

Functional, Anatomical, and Molecular Investigation of the Cardiac Conduction System and Arrhythmogenic Atrioventricular Ring Tissue in the Rat Heart

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2013
Background The cardiac conduction system consists of the sinus node, nodal extensions, atrioventricular (AV) node, penetrating bundle, bundle branches, and Purkinje fibers.
A. Atkinson, S. Logantha, G. Hao, J. Yanni, O. Fedorenko, A. Sinha, S. Gilbert, A. Benson, D. Buckley, Robert H. Anderson, M. Boyett, H. Dobrzynski   +11 more
semanticscholar   +1 more source

DC-DC Boost Converter with Constant Output Voltage for Grid Connected Photovoltaic Application System [PDF]

, 2010
The main purpose of this paper is to introduce an approach to design a DC-DC boost converter with constant output voltage for grid connected photovoltaic application system.
Chan, Pui Weng
core  

Electrocardiographic patch devices and contemporary wireless cardiac monitoring. [PDF]

, 2015
Cardiac electrophysiologic derangements often coexist with disorders of the circulatory system. Capturing and diagnosing arrhythmias and conduction system disease may lead to a change in diagnosis, clinical management and patient outcomes.
Carlson, SK, Chang, PM, Doshi, RN, Fung, E, Grazette, LP, Huikuri, HV, Järvelin, MR, Peters, NS, Sangha, RS, Shinbane, JS   +9 more
core   +2 more sources

Assessing proton plans with three different beam delivery systems versus photon plans for head and neck tumors

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To compare plan quality among photon volumetric modulated arc therapy (VMAT) and intensity‐modulated proton therapy (IMPT) with robustness using three different proton beam delivery systems with various spot size (σ) ranges: cyclotron‐generated proton beams (CPBs) (σ: 2.7–7.0 mm), linear accelerator proton beams (LPBs) (σ: 2.9–5.5 mm),
Tara Gray, Chieh‐Wen Liu, Saeed Ahmed, Anna Maria Kolano, Jeremy Donaghue, Shlomo Koyfman, Neil Woody, Shauna R. Campbell, Jonathan B. Farr, Ping Xia   +9 more
wiley   +1 more source

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium [PDF]

, 2009
Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to investigate regional and transmural distribution of sodium channel expression and function in the myocardium.
A. A. M. Wilde, A. O. Verkerk, B. P. Scicluna, C. A. Remme, C. Annink, C. R. Bezzina, J. M. T. Bakker, M. J. B. den Hoff, M. W. Veldkamp, T. A. B. Veen, V. M. Christoffels, W. M. H. Hoogaars, W. T. J. Aanhaanen   +12 more
core   +3 more sources

Conduction System Pacing vs Biventricular Pacing in Heart Failure and Wide QRS Patients: LEVEL-AT Trial.

JACC Clinical Electrophysiology, 2022
M. Pujol-López, R. Jiménez-Arjona, P. Garre, E. Guasch, R. Borrás, A. Doltra, E. Ferró, C. Garcia-Ribas, M. Niebla, Esther Carro, J. Puente, S. Vázquez-Calvo, E. Invers-Rubio, Ivo Roca-Luque, M. Castel, E. Arbelo, M. Sitges, J. Brugada, J. Tolosana, L. Mont   +19 more
semanticscholar   +1 more source

The effect of kV imaging dose on PTV and OAR planning constraints in lung SBRT using stereoscopic/monoscopic real‐time tumor‐monitoring system

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Quantify the impact of additional imaging doses on clinical dose constraints during lung stereotactic body radiotherapy (SBRT) treatment utilizing stereoscopic/monoscopic real‐time tumor monitoring. Materials and Methods Thirty lung SBRT patients treated with the volumetric arc therapy technique were randomly selected from the ...
Ruwan Abeywardhana, Mike Sattarivand
wiley   +1 more source

Classification and Prediction of Heart Diseases using Machine Learning Algorithms [PDF]

Heart disease is a serious worldwide health issue because it claims the lives of many people who might have been treated if the disease had been identified earlier. The leading cause of death in the world is cardiovascular disease, usually referred to as heart disease.
arxiv   +1 more source