Results 91 to 100 of about 543,934 (389)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Conduction system pacing: promoting the physiology to prevent heart failure [PDF]

, 2023
Han Naung Tun, Hafiza Khan, Daryna Chernikova, Yury Mareev, Santabhanu Chakrabarti, May Thant, Antonio Cannatà   +6 more
openalex   +1 more source

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease

Journal of Arrhythmia
Background Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders.
Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik   +12 more
doaj   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Electrophysiological Mechanisms of Atrial Flutter [PDF]

, 2006
Atrial flutter (AFL) is a common arrhythmia in clinical practice. Several experimental models such as tricuspid regurgitation model, tricuspid ring model, sterile pericarditis model and atrial crush injury model have provided important information about
Chen, Shin-Ann, Tai, Ching- Tai
core   +2 more sources

Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management [PDF]

, 2016
Atrioventricular block is classified as congeni- tal if diagnosed in utero, at birth, or within the first month of life. The pathophysiological process is believed to be due to immune-mediated injury of the conduction system, which occurs as a result
A Ambrosi, A Baban, A Brucato, A Dragulescu, A Gheissari, A Ruffatti, AC McCanta, AE Baruteau, AE Baruteau, AE Baruteau, AE Epstein, AJ Klein, AJ Rein, Alban-Elouen Baruteau, Albin Behaghel, BF Cuneo, BJ Wilhelm, BL Wilkoff, C Warnes, Christopher J. McLeod, CV DeSimone, D Takeuchi, DB McElhinney, DJ McCulley, DM Friedman, DY Mah, E Villain, E Villain, E1 Jaeggi, EA Stephenson, EB Fortescue, Elodie Perdreau, ET Jaeggi, ET Jaeggi, F Cecchin, FE Udink ten Cate, G Andelfinger, G Bergman, G Mathur, H Zhao, HM Spotnitz, HT Lynch, I Yildirim, J Bentham, J Janousek, J Janousek, J Janousek, J Kammeraad, J Sperzel, JB Thambo, JC Fouron, JD Forrester, Jean-Benoit Thambo, JJ Kim, JJ Schott, JJ Schott, JP Buyon, JP Moak, JP Moak, K Takahashi, KA McLeod, KG Schmidt, KL Lee, L Liberman, L Liberman, Leonardo Liberman, M Arce, M Brignole, M Emmel, M Michaelsson, M Michaëlsson, M Taketazu, ME Kleinman, MI Cohen, MO Sweeney, MR Rosen, MS Silvetti, MS Silvetti, MS Silvetti, MT Donofrio, N Costedoat-Chalumeau, N Makita, N Modi, Nicolas Combes, O Hunscher, P Bordachar, P Deshmukh, P Kabunga, P Khairy, P Kubus, P Zartner, PC Gazes, PE Lazzerini, PL Stojanov, PV Taylor, R Robledo-Nolasco, RH Anderson, RJ Kanter, Robert H. Pass, RS Assad, S Tsao, S Tung, S Zaidi, SG Priori, SN Barra, Solène Le Pennec, U Krause, VX Mosquera, VY Reddy, W Lotfy, Y-F Hu   +110 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. [PDF]

, 2016
Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies.
Abdallah, Walid F, Choi, Jongkyu, Comai, Lucio, Dansithong, Warunee, Dixon, Donald M, Jordan, Maria C, Lee, Han Shin, Reddy, Sita, Roos, Kenneth P, Trac, Brandon   +9 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source