Results 61 to 70 of about 1,271,305 (362)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Cardiac Tissue Mapping Electrode Array to Determine Pro-Arrhythmic Tissue Substrates [PDF]

, 2016
Myocardial infarction (MI), commonly known as a heart attack, is the irreparable necrosis of the cardiac tissue due to sustained ischemia. MI may lead to heart failure.
Shannon, Thomas Mark
core   +1 more source

Cryoablation: how to improve results in atrioventricular nodal reentrant tachycardia ablation? [PDF]

, 2010
Ablation for atrioventricular nodal reentry tachycardia is very effective, with a potential for damage to the normal conduction system. Cryoablation is an alternative, as it allows cryomapping, which permits assessment of slow pathway elimination at ...
Avari, B. Schwagten, Collins, Dubuc, Friedman, Gill, Harrison, Holman, Jensen-Urstad, Khairy, Kimman, Kuniss, L. Jordaens, Lustgarten, Mikat, Opel, Rivard, Stewart, Theuns, Thornton, Thornton, Y. Van Belle, Zrenner   +22 more
core   +2 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

All-Optical 4D In Vivo Monitoring And Manipulation Of Zebrafish Cardiac Conduction [PDF]

, 2015
The cardiac conduction system is vital for the initiation and maintenance of the heartbeat. Over the recent years, the zebrafish (Danio rerio) has emerged as a promising model organism to study this specialized system.
Weber, Michael
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Visualization of the Cardiac Excitation and PVC Arrhythmia on a 3D Heart Model [PDF]

, 2017
Visualization of the cardiac potential movement is important in understanding the physiology of the human heart. A 3D visualization tool will help the cardiology students and others interested in human physiology to understand the functioning of the ...
Sreedharan Veliyara, Pranav
core   +1 more source

Ventricular Conduction System Modeling for Electrophysiological Simulation of the Porcine Heart [PDF]

, 2022
Depolarization sequences triggering mechanical contraction of the heart are largely determined by the cardiac conduction system (CS). Many biophysical models of cardiac electrophysiology still have poor representations of the CS.
Doblare, M, Mazo, MM, Mountris, KA, Pueyo, E, Rosales, RM   +4 more
core  

Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death

Cardiovascular Research, 2020
Aims Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse
D. Filgueiras-Rama, Jasmina Vasilijevic, J. Jalife, Sami F. Noujaim, J. M. Alfonso, J. A. Nicolás-Ávila, Celia Gutierrez, Noelia Zamarreño, A. Hidalgo, Alejandro Bernabé, C. Cop, Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Daniel Calle, M. Desco, J. Ruíz-Cabello, A. Nieto, A. Falcón   +17 more
semanticscholar   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source