Results 81 to 90 of about 543,934 (389)

Erbb2 is required for cardiac atrial electrical activity during development.

PLoS ONE, 2014
The heart is the first organ required to function during embryonic development and is absolutely necessary for embryo survival. Cardiac activity is dependent on both the sinoatrial node (SAN), which is the pacemaker of heart's electrical activity, and ...
Gennadiy Tenin, Christopher Clowes, Kathryn Wolton, Eliska Krejci, Jayne A Wright, Simon C Lovell, David Sedmera, Kathryn E Hentges   +7 more
doaj   +1 more source

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis [PDF]

, 2016
Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcomes. This study
Barker, Diane, Beynon, Rhys, Buchan, Iain, Kwok, Chun Shing, Loke, Yoon K, Mamas, Mamas A, Morley-Davies, Adrian, Myint, Phyo K, Nolan, James, Patwala, Ashish, Rashid, Muhammad, Satchithananda, Duwarakan   +11 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. [PDF]

, 2017
In this issue of EMBO Molecular Medicine, Decher et al (2017) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) ventricular
Goldstein, Steve An
core   +2 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Conduction System Pacing in Children and Congenital Heart Disease

Arrhythmia & Electrophysiology Review
Permanent cardiac pacing in children with congenital complete atrioventricular block (CCAVB) and/or congenital heart disease (CHD) is challenging.
Óscar Cano, Jeremy P Moore
doaj   +1 more source

Restoring heart function and electrical integrity: closing the circuit

npj Regenerative Medicine, 2017
Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity.
Luís Miguel Monteiro, Francisco Vasques-Nóvoa, Lino Ferreira, Perpétua Pinto-do-Ó, Diana Santos Nascimento   +4 more
doaj   +1 more source

CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]

, 2014
Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core   +2 more sources

Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death

Cardiovascular Research, 2020
Aims Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse
D. Filgueiras-Rama, Jasmina Vasilijevic, J. Jalife, Sami F. Noujaim, J. M. Alfonso, J. A. Nicolás-Ávila, Celia Gutierrez, Noelia Zamarreño, A. Hidalgo, Alejandro Bernabé, C. Cop, Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Daniel Calle, M. Desco, J. Ruíz-Cabello, A. Nieto, A. Falcón   +17 more
semanticscholar   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source