Results 61 to 70 of about 5,469,873 (362)

Weight Loss in Obese Patients With Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIn heart failure (HF), weight loss (WL) has been associated with an adverse prognosis whereas obesity has been linked to lower mortality (the obesity paradox). The impact of WL in obese patients with HF is incompletely understood. Our objective
Elisabet Zamora, Carles Díez‐López, Josep Lupón, Marta de Antonio, Mar Domingo, Javier Santesmases, María Isabel Troya, Crisanto Díez‐Quevedo, Salvador Altimir, Antoni Bayes‐Genis   +9 more
doaj   +1 more source

‘Mitotherapy’ for Heart Failure

Trends in Molecular Medicine, 2016
Abnormalities in mitochondrial dynamics along with those for the molecular mediators involved are presently being viewed with increased interest in the field of cardiovascular disease. Recent research highlights OPA1, a dynamin-like GTPase mediating mitochondrial fusion, as well as the 'mitoproteases' OMA1 and YME1L, as potential therapeutic targets ...
Sanchis Gomar, Fabian, LIPPI, Giuseppe, Lucia, Alejandro   +2 more
openaire   +5 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Single Center Experience With Impella 5.5 for Escalation and De-Escalation of Cardiogenic Shock Patients

Journal of Interventional Cardiology
Temporary mechanical circulatory support (tMCS) devices are a critical component for treating patients with cardiogenic shock (CS). We analyzed use of Impella 5.5 device for efficacy and safety in a single-center CS population from February 2022 and ...
Ioana Dumitru, Debbie Rinde-Hoffman, Maria Sevillano, Leeandra Schnell, Elizabeth Quintilliani, Swaroop Bommareddi   +5 more
doaj   +1 more source

Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals

Molecular Imaging, 2022
Background. Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging.
Yohji Matsusaka, Rudolf A. Werner, Paula Arias-Loza, Naoko Nose, Takanori Sasaki, Xinyu Chen, Constantin Lapa, Takahiro Higuchi   +7 more
doaj   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Association between the Length of Hospital Stay and 30-Day Outcomes in Patients Admitted with Acute Decompensated Heart Failure

Emergency Medicine International, 2023
Background and Aim. Regarding patients admitted with acute decompensated heart failure (ADHF), there are inconsistent reports surrounding the association between length of stay (LOS) and mortality or rehospitalization following discharge.
Melika Namvar, Mohammad Fakhrolmobasheri, Sadegh Mazaheri-Tehrani, Maryam Heidarpour, Maryam Emamimeybodi, Davood Shafie   +5 more
doaj   +1 more source

Sodium-glucose co-transporter 2 inhibitor therapy: mechanisms of action in heart failure [PDF]

, 2021
Shruti Joshi, Trisha Singh, David E. Newby, Jagdeep Singh   +3 more
openalex   +1 more source

Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial

European Journal of Heart Failure, 2021
Sodium–glucose co‐transporter 2 (SGLT2) inhibitors, originally developed as glucose‐lowering agents, have been shown to reduce heart failure hospitalizations in patients with type 2 diabetes without established heart failure, and in patients with heart ...
S. Solomon, Rudolf A. de Boer, D. DeMets, Adrian F. Hernandez, S. Inzucchi, M. Kosiborod, C. Lam, F. Martinez, Sanjiv J. Shah, D. Lindholm, U. Wilderäng, F. Öhrn, B. Claggett, A. Langkilde, Magnus Petersson, J. McMurray   +15 more
semanticscholar   +1 more source

Lungs in Heart Failure [PDF]

Pulmonary Medicine, 2012
Lung function abnormalities both at rest and during exercise are frequently observed in patients with chronic heart failure, also in the absence of respiratory disease. Alterations of respiratory mechanics and of gas exchange capacity are strictly related to heart failure.
Anna Apostolo, Giuliano Giusti, Paola Gargiulo, Maurizio Bussotti, Piergiuseppe Agostoni   +4 more
openaire   +4 more sources