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The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions
FEBS Letters, 2007The human heat shock protein 70 (Hsp70) family contains at least eight homologous chaperone proteins. Endoplasmatic reticulum and mitochondria have their specific Hsp70 proteins, whereas the remaining six family members reside mainly in the cytosol and ...
M. Daugaard, M. Rohde, M. Jäättelä
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Heat Shock Protein 70 and Cancer
, 2018Heat shock proteins (HSP) constitute a large family of proteins involved in protein folding and maturation and the expressions of HSP are induced by heat shock or other stressors. The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSP (HSP110 and glucose-regulated protein 170 ...
Tuo-En Liu, Shou-Song Cao
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Heat Shock Response of Babesia gibsoni Heat Shock Protein 70
Journal of Parasitology, 2008mRNA and protein expression profiles for heat shock protein 70 (Hsp70) of Babesia gibsoni (BgHsp70) exposed to either high or low temperatures, were examined by quantitative real-time reverse transcription-polymerase chain reaction and Western blotting.
Masahiro, Yamasaki +5 more
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Binding of Heat-Shock Protein 70 (hsp70) to Tubulin
Archives of Biochemistry and Biophysics, 1994Binding of heat-shock protein (hsp70) to polymerized tubulin has been investigated by in vitro experiments. The tubulin region involved in binding to hsp70 corresponds to the carboxy-terminal residues 431-444, also involved in the association with other microtubule-associated proteins (MAPs).
Sánchez, Carlos +4 more
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Clinical Biochemistry, 2016
Heat shock proteins (Hsps) are produced by all cells, including vascular, to ensure stress protection. Damaged cells release Hsps in their local environment and systemic circulation. The aim of this study was to investigate the involvement and prognostic utility of serum Hsp60 and Hsp70, and the respective antibodies anti-Hsp60 and anti-Hsp70 in ...
Galović, Ružica +4 more
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Heat shock proteins (Hsps) are produced by all cells, including vascular, to ensure stress protection. Damaged cells release Hsps in their local environment and systemic circulation. The aim of this study was to investigate the involvement and prognostic utility of serum Hsp60 and Hsp70, and the respective antibodies anti-Hsp60 and anti-Hsp70 in ...
Galović, Ružica +4 more
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Therapeutic Use of Heat Shock Protein 70
Recent Patents on DNA & Gene Sequences, 2007All living organisms use protein to perform essential functions. However, environmental factors induce stress and relevant proteins that may not function properly. Inappropriate misfolding and aggregation are major issues in functioning of a protein and this may impact critical cellular processes implicated in diseases.
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Archives of Dermatological Research, 1994
Autoimmunity and microbial agents have been suggested as playing a pathogenetic role in psoriasis. Since immune responses to microbial infections are often directed towards heat shock proteins (HSP), we investigated the expression of three HSP families in normal and inflamed human skin. Specimens from ten patients with psoriasis and three patients with
Boehncke, Wolf-Henning +3 more
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Autoimmunity and microbial agents have been suggested as playing a pathogenetic role in psoriasis. Since immune responses to microbial infections are often directed towards heat shock proteins (HSP), we investigated the expression of three HSP families in normal and inflamed human skin. Specimens from ten patients with psoriasis and three patients with
Boehncke, Wolf-Henning +3 more
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Identification of heat shock protein 70 in the rabies virion
Virology, 1992We investigated a 73-kDa polypeptide (p73), a minor component of the rabies virion (HEP-Flury and ERA strains), accounting for as much as 1% of total virion proteins. Two-dimensional gel electrophoresis and immunoblotting with the antiserum against the heat shock protein 70 (hsp70) demonstrated that p73 was identical to a constitutive type of cellular ...
J, Sagara, A, Kawai
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Multifaceted Role of Heat Shock Protein 70 in Neurons
Molecular Neurobiology, 2010Heat shock protein 70 (Hsp70) plays important roles in neural protection from stress by assisting cellular protein folding. In this review we discuss the current understanding of inducible and constitutive Hsp70 in maintaining and protecting neuronal synaptic function under normal and stressed conditions.
Tom Z, Lu, Yi, Quan, Zhong-Ping, Feng
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Immunohistochemical expression of heat shock protein 70 in vitiligo
Annals of Diagnostic Pathology, 2013Heat shock proteins (HSPs) are proteins that are expressed under variety of stresses including pathologic conditions. How stresses affect vitiligo is not fully understood and little is known about the role of HSPs generally and Hsp70 specifically in vitiligo.
Asmaa Gaber, Abdou +2 more
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