Results 31 to 40 of about 7,058,225 (244)

RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Nature Communications, 2019
Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction and other whole-joint pathological changes. There is currently no effective disease-modifying therapy.
Young-Ok Son, Hyo-Eun Kim, W. Choi, Churl-Hong Chun, Jang-Soo Chun   +4 more
semanticscholar   +1 more source

Molecular characterization of heat shock protein 70 gene in Iraqi buffalo [PDF]

Iraqi Journal of Veterinary Sciences, 2020
The heat shock protein 70 (HSP 70) has important roles in protecting cells and keeping them alive when exposed to different stress conditions. The polymorphism of the hsp 70 gene could be linked with the ability of stress tolerance.
Hassan N. Habib
doaj   +1 more source

Exploration of Benzothiazole-Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

Journal of Medicinal Chemistry, 2018
Cancer cells rely on the chaperone, heat shock protein 70 (Hsp70), for survival and proliferation. Recently, benzothiazole-rhodacyanines have been shown to bind an allosteric site on Hsp70, interrupting its binding to nucleotide-exchange factors (NEFs ...
H. Shao, Xiaokai Li, M. Moses, Luke A. Gilbert, C. Kalyanaraman, Zapporah T. Young, M. Chernova, Sara N Journey, J. Weissman, B. Hann, M. Jacobson, L. Neckers, J. Gestwicki   +12 more
semanticscholar   +1 more source

Heat shock protein 70 promotes lipogenesis in HepG2 cells

Lipids in Health and Disease, 2018
Background The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has followed the international rise in obesity rates. Multiple mechanisms are involved in NAFLD, including endoplasmic reticulum stress and oxidative stress.
Jielei Zhang, Nengguang Fan, Yongde Peng
doaj   +1 more source

Implications of sperm heat shock protein 70-2 in bull fertility [PDF]

Veterinary World, 2022
Heat shock protein 70 (HSP70) is one of the most abundant chaperone proteins. Their function is well documented in facilitating the protein synthesis, translocation, de novo folding, and ordering of multiprotein complexes.
Zulfi Nur Amrina Rosyada, Mokhamad Fakhrul Ulum, Ligaya I. T. A. Tumbelaka, Dedy Duryadi Solihin, Bambang Purwantara, Erdogan Memili   +5 more
doaj   +1 more source

Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.

American Journal of Respiratory Cell and Molecular Biology, 2019
Idiopathic pulmonary fibrosis (IPF) pathogenesis has been postulated to involve a variety of mechanisms associated with the aging process, including loss of protein homeostasis (proteostasis).
J. Sellarés, K. Veraldi, Katelynn J. Thiel, N. Cardenes, D. Álvarez, F. Schneider, J. Pilewski, M. Rojas, C. Feghali-Bostwick   +8 more
semanticscholar   +1 more source

Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans [PDF]

, 2012
Hsp12p is considered to be a small heat shock protein and conserved among fungal species. To investigate the expression of this heat shock protein in the fungal pathogen Candida albicans we developed an anti-CaHsp12p antibody.
Mühlschlegel, Fritz A., Fritz A. Mühlschlegel, De Sordi Luisa, Luisa De Sordi (146209), Fritz A. Mühlschlegel (146212), Fu Man-Shun, De Sordi, L, Fu, Man Shun, Fu, MS, Fritz A Mühlschlegel, Man-Shun Fu, Luisa De Sordi, Mühlschlegel Fritz A., De Sordi, Luisa, Mühlschlegel, FA, Luisa De Sordi¤b, Man-Shun Fu (146203)   +16 more
core   +1 more source

Membrane heat shock protein 70: a theranostic target for cancer therapy

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
Members of the 70 kDa stress protein family are found in nearly all subcellular compartments of nucleated cells where they fulfil a number of chaperoning functions.
M. Shevtsov, Hui-Le Gao, G. Multhoff
semanticscholar   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
Stuart, Rosemary A., Neupert, Walter, Cyr, Douglas M.   +2 more
core   +1 more source

Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis [PDF]

, 2001
Background—Studies have suggested that the prevalence of antibodies against heat-shock proteins (HSPs), Chlamydia pneumoniae (Cpn), and cytomegalovirus (CMV) is associated with coronary artery disease (CAD), but the independent or joint effects of ...
Virók Dezső, Gönczöl Éva, Prohászka Zoltán, Burián, Katalin, Endrész Valéria, Duba Jenő, Füst György, Kis, Zoltán, Virók, Dezső, Endrész, Valéria, Duba, Jenő, Boda, Krisztina, Berencsi Klára, Berencsi, Klára, Kis Zoltán, Romics, László, Romics László, Gönczöl, Éva, Prohászka, Zoltán, Horváth, Laura, Boda Krisztina, Burián Katalin, Horváth Laura, Füst, György   +23 more
core   +2 more sources