Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? [PDF]
For many years, heat shock or stress proteins have been regarded as intracellular molecules that have a range of housekeeping and cytoprotective functions, only being released into the extracellular environment in pathological situations such as necrotic
Pockley, A.G.
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Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins [PDF]
The activity of the Arabidopsis heat shock transcription factor (HSF) is repressed at normal conditions but activated by cellular stresses. Circumstantial evidence suggests that HSP70 may function as a negative feedback regulator of HSF activity. Here the interaction between HSF and HSP70 is reported using electrophoretic mobility shift and yeast two ...
Byung-Hoon, Kim, Fritz, Schöffl
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Stress proteins of Clostridium perfringens type A immunoreact with antiserum from rabbits infected with gas gangrene [PDF]
Various stressors were used to induce stress proteins in Clostridium perfringens. Cultures of C. perfringens FD-1041 were subjected to cold shock (28°C for 1 h), acid shock (pH 4.5 for 30 min), or heat shock (50°C for 30 min).
Elva Aréchiga +3 more
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Cold cardioplegic arrest enhances heat shock protein 70 in the heat-shocked rat heart [PDF]
Myocardial content of the 70-kd heat shock protein has been found to correlate with improved cardiac recovery after ischemia, but the mechanisms and conditions that regulate its level, particularly under clinical conditions, are unclear. The aim of this study was to assess the effect of hypothermic cardioplegic arrest and reperfusion on the expression ...
Gray, Caroline C. +4 more
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Background Bronchial thermoplasty regulates structural abnormalities involved in airway narrowing in asthma. In the present study we aimed to investigate the effect of bronchial thermoplasty on histopathological bronchial structures in distinct asthma ...
Eleni Papakonstantinou +9 more
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Downregulated expression of HSP27 in human low-grade glioma tissues discovered by a quantitative proteomic analysis [PDF]
Background Heat shock proteins (HSPs), including mainly HSP110, HSP90, HSP70, HSP60 and small HSP families, are evolutionary conserved proteins involved in various cellular processes.
Guobo Shen +9 more
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Autoimmunity and microbial agents have been suggested as playing a pathogenetic role in psoriasis. Since immune responses to microbial infections are often directed towards heat shock proteins (HSP), we investigated the expression of three HSP families in normal and inflamed human skin. Specimens from ten patients with psoriasis and three patients with
Boehncke, Wolf-Henning +3 more
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Comparative modeling and mutual docking of structurally uncharacterized heat shock protein 70 and heat shock factor-1 proteins in water buffalo [PDF]
Aim: In this study, a wide range of in silico investigation of Bubalus bubalis (BB) heat shock protein 70 (HSP70) and heat shock factor-1 (HSF1) has been performed, ranging from sequence evaluation among species to homology modeling along with their ...
Ravinder Singh +7 more
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Anti–Heat Shock Protein 70 Antibodies in Meniere's Disease [PDF]
AbstractObjectives To determine the prevalence of anti–heat shock protein 70 (anti‐HSP70) antibodies in patients with Meniere's disease and healthy subjects and to probe the relationship between antibody status and clinical features of Meniere's disease.Study Design Prospective cohort study of consecutive consenting patients with Meniere's disease ...
S D, Rauch +3 more
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Trypanosoma congolense heat-shock protein 70 : a promising TH1 adjuvant [PDF]
Developing immunopotentiators to improve vaccine efficacy in ruminants is an important goal. Heat shock proteins (HSPs) have been shown to act as adjuvant when co-administrated with peptides antigens or given as fusion proteins.
Authié, Edith +7 more
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