Results 251 to 260 of about 321,164 (352)

Preserve or destroy: Orphan protein proteostasis and the heat shock response. [PDF]

J Cell Biol
Ali A, Paracha S, Pincus D.
europepmc   +1 more source

HAEMATOLOGICAL RESPONSES OF NIGERIAN LOCALLY ADAPTED CHICKENS WITH DIFFERENT HEAT SHOCK PROTEIN 70 GENOTYPES TO ACUTE HEAT STRESS

Rasheed Fatai, M. O. Akinyem, O. H. Osaiyuwu, K. M. Ewuola, A. E. Salako   +4 more
openalex   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Feedback control of the heat shock response by spatiotemporal regulation of Hsp70. [PDF]

J Cell Biol
Garde R, Dea A, Herwig MF, Ali A, Pincus D.   +4 more
europepmc   +1 more source

Heat shock response: presence and effects in burn patient neutrophils [PDF]

, 1999
David A. Rodeberg, Joseph G Meyer, George F. Babcock   +2 more
openalex   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Activation of the heat shock response as a therapeutic strategy for tau toxicity. [PDF]

Dis Model Mech
Stanley TR, Otero EM, Knight AL, Saxton AD, Ding X, Borgen M, Kraemer BC, Kim Guisbert KS, Guisbert E.   +8 more
europepmc   +1 more source

The immunophilin‐ligands FK506 and V‐10,367 mediate neuroprotection by the heat shock response [PDF]

, 2003
Alexa Klettner, Thomas Herdegen
openalex   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis. [PDF]

Open Life Sci
Zhou J, Lu X, Xie Y, Mao G.
europepmc   +1 more source