Results 61 to 70 of about 321,164 (352)

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
Axel Walch, Alan G Pockley, Foulds, GA, Pockley, A. G., Foulds, G. A., Doss, B. T., Pockley, AG, Stangl Stefan, Kirschner, A., Foulds, G.A., Gehrmann, M., Multhoff, G., Walch Axel, Doß Brigitte T., Walch, A.K., Kirschner, A, Gehrmann Mathias, Gemma A Foulds, Stangl, S., Walch, A., Doß, B.T., Pockley, A.G., Multhoff, G, Sievert Wolfgang, Stefan Stangl, Stangl, S, Pockley Alan G., Mathias Gehrmann, Multhoff Gabriele, Sievert, W, Sievert, W., Foulds Gemma A., Andreas Kirschner, Kirschner Andreas, Wolfgang Sievert, Gehrmann, M, Gabriele Multhoff, Doß, BT, Brigitte T Doss, Walch, A   +39 more
core   +1 more source

Role of BRCA1 in heat shock response [PDF]

Oncogene, 2003
The heat shock response is an evolutionarily conserved response to heat and other stresses that promotes the maintenance of key metabolic functions and cell survival. We report that exposure of human prostate (DU-145) and breast (MCF-7) cancer cells to heat (42 degrees C) caused a rapid disappearance of the breast cancer susceptibility gene-1 (BRCA1 ...
Yong, Xian Ma, Saijun, Fan, Jingbo, Xiong, Ren-Qi, Yuan, Qinghui, Meng, Min, Gao, Itzhak D, Goldberg, Suzanne A, Fuqua, Richard G, Pestell, Eliot M, Rosen   +9 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Prior exposure strongly influences mechanisms underpinning survival of heat shock in Escherichia coli

Frontiers in Microbiology
The heat shock response of Escherichia coli represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation.
Muhammad Yasir, Muhammad Yasir, A. Keith Turner, A. Keith Turner, Sarah Bastkowski, Sarah Bastkowski, Caroline S. Jarvis, Caroline S. Jarvis, Caroline S. Jarvis, Ryan Sweet, Ryan Sweet, Megan Truong, Megan Truong, Megan Truong, Megan Truong, Ian G. Charles, Ian G. Charles, Ian G. Charles, Mark A. Webber, Mark A. Webber, Mark A. Webber   +20 more
doaj   +1 more source

Cloning and characterisation of heat shock and wound-induced genes in pea (pisum sativum L.) [PDF]

, 1997
Plant productivity in many regions of the world is limited primarily as a result of environmental stresses. High temperature and wounding caused by pest and pathogen infection are among the main factors accounting for unpredictable and often severe yield
Dhankher, Om Parkash
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Characterizing primary transcriptional responses to short term heat shock in Down syndrome.

PLoS ONE
Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21.
Joseph F Cardiello, Jessica Westfall, Robin Dowell, Mary Ann Allen   +3 more
doaj   +1 more source

Mechanism of protonophores-mediated induction of heat-shock response in Escherichia coli

BMC Microbiology, 2009
Background Protonophores are the agents that dissipate the proton-motive-force (PMF) across E. coli plasma membrane. As the PMF is known to be an energy source for the translocation of membrane and periplasmic proteins after their initial syntheses in ...
Saha Swati, Panja Subrata, Jana Bimal, Basu Tarakdas   +3 more
doaj   +1 more source

Menin links the stress response to genome stability in Drosophila melanogaster. [PDF]

PLoS ONE, 2010
The multiple endocrine neoplasia type I gene functions as a tumor suppressor gene in humans and mouse models. In Drosophila melanogaster, mutants of the menin gene (Mnn1) are hypersensitive to mutagens or gamma irradiation and have profound defects in ...
Maria Papaconstantinou, Alicia N Pepper, Ying Wu, Dahlia Kasimer, Tim Westwood, Ana Regina Campos, Pierre-André Bédard   +6 more
doaj   +1 more source

Correction: Heat shock response in archaea [PDF]

Emerging Topics in Life Sciences, 2018
Emerging Topics in Life Sciences (2018) https://doi.org/10.1042/ETLS20180024 In the Ahead-of-Print version published on 22 November 2018, the titles/captions for [Figures 1][1] and [3][2] were accompanied by the wrong artwork.
Liesbeth, Lemmens, Rani, Baes, Eveline, Peeters   +2 more
openaire   +2 more sources