Results 161 to 170 of about 274,892 (263)

Heat shock proteins at the crossroads of endosomal trafficking pathways. [PDF]

Cell Biol Toxicol
Zuppini F, Renzullo L, Tornatore F, Poggio P, Brancaccio M.   +4 more
europepmc   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Evolution uncovers a general tradeoff between recovery after heat shock and growth at elevated temperatures. [PDF]

mBio
Mall A, Rode KJ, Marx CJ.
europepmc   +1 more source

Ti‐Doping Activates Adjacent Zr Sites in Bimetallic MOFs for Cooperative Phospholipid Removals in Human Biomonitoring

Advanced Science, EarlyView.
Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang, Hongyue Ma, Feier Bai, Jing Zhang, Yan Qi, Bing Shao   +5 more
wiley   +1 more source

Placental Heat Shock Protein (HSP) Expression in Fetal Growth Restriction (FGR) Pregnancies: A Case-Control Immunohistochemistry Study. [PDF]

Int J Mol Sci
Samara AA, Janho MB, Zacharouli K, Floros T, Ioannou M, Garas A, Karachrysafi S, Papamitsou T, Messini CI, Daponte A, Sotiriou S.   +10 more
europepmc   +1 more source

Origami Metamaterials Based on Low‐Melting‐Point Alloy Phase Transition: Breaking the Trade‐Off Between Reusability and Energy Absorption Quality

Advanced Science, EarlyView.
This work presents an origami metamaterial that integrates a low‐melting‐point alloy skeleton into an elastomeric shell. It dissipates energy through the metal's plastic deformation and recovers through the solid–liquid phase transition of the alloy together with the hyperelasticity of the shell.
Yupeng Liu, Wei Zhao, Chengjun Zeng, Jiuming Fan, Yanju Liu, Jinsong Leng   +5 more
wiley   +1 more source

Transgenerational effects of heat shock on gene regulation and fitness-related traits in natural Drosophila populations. [PDF]

Mol Biol Evol
Harney E, González J.
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Heat Shock Proteins in Medically Relevant Fungal Pathogens: From Molecular Chaperones to Virulence Factors and Therapeutic Targets. [PDF]

J Fungi (Basel)
Padró-Villegas L, Mora-Montes HM.
europepmc   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source