Results 181 to 190 of about 198,852 (250)

Non‐Equilibrium Synthesis of Whitlockite Assisted by Localized H2O Vapor Pressure

Advanced Science, EarlyView.
A carbon substrate acts as a microheater during intense pulsed light irradiation, enabling rapid heating and cooling for whitlockite formation. In contrast to conventional white ceramic synthesis with weak photothermal response, this platform concentrates thermal energy locally and promotes phase‐selective crystallization under ultrafast ...
Min‐Jung Kim, Minwoo Lee, In‐Ho Jung, Seung‐Kyun Kang, Ji‐Soo Jang, Hyung‐Seop Han   +5 more
wiley   +1 more source

Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA. [PDF]

EMBO J, 2020
Kmiecik SW, Le Breton L, Mayer MP.
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report.

Blood, 2021
Hoff FW, van Dijk AD, Qiu Y, Ruvolo PP, Gerbing RB, Leonti AR, Jenkins GN, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, de Bont ESJM, Bruggeman SWM, Kornblau SM, Horton TM.   +15 more
europepmc   +1 more source

Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1. [PDF]

Biosci Rep, 2020
Chen BC, Tu SL, Zheng BA, Dong QJ, Wan ZA, Dai QQ.   +5 more
europepmc   +1 more source

Synergistic Interface Engineering via Buffer Layer and UVO Treatment for High‐Performance PbS Quantum Dot Near‐Infrared Photodiodes

Advanced Science, EarlyView.
A dual‐interface strategy combining a solvent‐orthogonal Poly‐TPD buffer with UV–ozone tuning of PbS‐EDT reconstructs interfacial energetics and defect chemistry in PbS CQD photodiodes. The optimized interface suppresses shunt‐ and trap‐related leakage, reduces noise, and enables high‐detectivity near‐infrared detection with imaging capability ...
Chuan Wei, Jun Han, Ning Feng, Li Yan, Hao Sun, Yuanhong Gao, Meili Xu, Guodan Wei, Hong Meng   +8 more
wiley   +1 more source

Excitatory synapse impairment and mitochondrial dysfunction in Huntington's disease: heat shock factor 1 (HSF1) converging mechanisms. [PDF]

Neural Regen Res, 2020
Zarate N, Gomez-Pastor R.
europepmc   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source