Results 151 to 160 of about 467,674 (297)

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Heat Shock Protein 47 as a Novel Predictive and Diagnostic Biomarker for Thrombosis in Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Wang ZG, Peng Y, Wei WY, Liu P, Zhao R, Liu MF.   +5 more
europepmc   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteome. [PDF]

Cell Stress Chaperones
Rios EI, Johnson JL.
europepmc   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Heat shock protein 10 as a chaperone modulating α-synuclein amyloid fibril formation. [PDF]

Protein Sci
Larsson JNK, Kumar R, Buratti FA, Nyström S, Wittung-Stafshede P, Hammarström P.   +5 more
europepmc   +1 more source

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Molecular Mechanisms of the Phytohormone-Heat Shock Protein Pathway in Regulating Plant Thermotolerance. [PDF]

Plants (Basel)
Zhang J, Zhu Y, Ma F, Zou X, Lan Q, Zhou X, Li M, Zhou F, Yin C, Lin Y.   +9 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation. [PDF]

Biomedicines
Kalantidou A, Kostakou M, Deiktakis M, Chaniotis V, Goutakoli P, Liapakis G, Dermitzaki E, Tzardi M, Venihaki M.   +8 more
europepmc   +1 more source