Results 191 to 200 of about 270,723 (313)

Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation. [PDF]

Biomedicines
Kalantidou A, Kostakou M, Deiktakis M, Chaniotis V, Goutakoli P, Liapakis G, Dermitzaki E, Tzardi M, Venihaki M.   +8 more
europepmc   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Comparative genomic and evolutionary analysis of the heat shock protein gene family in the chicken genome. [PDF]

Anim Biotechnol
Wadood AA, Rehman SU, Bordbar F, Zhang X.   +3 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Photothermal-Responsive Phase Transition of Proteoliposomes for Heat Shock Protein Sequestering against Cancer Thermoresistance. [PDF]

Research (Wash D C)
Cheng K, Cheng K, Han Y, Zhang F, Li B, Zeng B, Zhao YD, Xia J.   +7 more
europepmc   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis [PDF]

, 2002
Joseph A. Mangan, Richard Stabler, Philip D. Butcher, Butcher, PD, Wernisch, L, Lorenz Wernisch, Ken G. Laing, Graham R. Stewart, Young, DB, Stabler, R, Hinds, J, Mangan, JA, Jason Hinds, Wermisch, L, Stewart, GR, Laing, KG, Douglas B. Young   +16 more
core   +1 more source

Maternal Heat Shock Protein as a Potential Biomarker of Adaptation to Heat Stress during Pregnancy and Its Relation to Preterm Birth. [PDF]

Environ Sci Technol
Yang X, Hu Y, Pardo N, Xu Y, Khalili R, Wolf-Jacobs A, Eckel SP, Niu Z, Yang T, Chen X, Foley H, Guardado D, Grubbs B, Al-Marayati L, Toledo-Corral CM, Johnston J, Dunton GF, Farzan SF, Bastain TM, Habre R, Breton CV.   +20 more
europepmc   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

[Expression of Concern] Pifithrin‑μ is efficacious against non‑small cell lung cancer via inhibition of heat shock protein 70. [PDF]

Oncol Rep
Zhou Y, Ma J, Zhang J, He L, Gong J, Long C.   +5 more
europepmc   +1 more source