Results 231 to 240 of about 270,723 (313)

Tailored Nanogel Network Topology Enables Clinical Ultrasound‐Induced Mechanochemical Activation for In Vivo Therapy

Angewandte Chemie, EarlyView.
The strategy of engineering nanogel network topology is developed to achieve iterative activation of mechanophores upon high‐frequency and low‐intensity ultrasound. This places the nanogel system among the systems that can respond to the ultrasound with the highest frequency and lowest intensity as well as have the fastest activation rate so far.
Helin Li, Fangyin Song, Xiaoye Hu, Li Jing, Qi Shuai, Weike Su, Andrij Pich, Xin Li   +7 more
wiley   +2 more sources

HSPA5, a Host Cellular Heat-Shock Protein Required for Influenza a Virus Replication. [PDF]

Int J Mol Sci
Rashid MU, Yasmin T, Coombs KM.
europepmc   +1 more source

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source

DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1

Angewandte Chemie, EarlyView.
Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe, Hiroyuki Kumeta, Tomohide Saio   +2 more
wiley   +2 more sources

Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [PDF]

Adv Sci (Weinh)
Wang C, Leng M, Sun C, Cao J, Li L, Jia Y, Han Y, Liu Y, Zhang Y, Zhang C, Men Y, Liu N, Cheng Y, Zhang Y, Li Y, Li Z, Cui L, Zhu X.   +17 more
europepmc   +1 more source

Heat Shock Protein and Immunity

Japanese journal of leprosy, 1995
openaire   +3 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +2 more sources

Sarcolipin but not phospholamban responds to <i>in-vivo</i> heat stress in rat skeletal muscle similar to the 70-kDa heat shock protein. [PDF]

Front Physiol
Brahmbhatt AN, Chan JZ, Tomczewski MV, Humaid A, Gallichan HI, Flanagan J, Duncan RE, Tupling AR.   +7 more
europepmc   +1 more source

The value of plasma levels of heat shock protein 90α for predicting the treatment efficacy and prognosis of lung cancer. [PDF]

Discov Oncol
Wang B, Ma Y, Zhang Y, Li J, Liu H, Jing N.   +5 more
europepmc   +1 more source