Results 241 to 250 of about 5,347,852 (306)

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Single-cell transcriptomics reveal heat shock protein dysregulation in severe SARS-CoV-2-associated pediatric encephalopathy. [PDF]

Sci Rep
Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iwata KI, Yamaguchi M, Kawamura Y, Yoshikawa T, Kimura H, Kawada JI, Torii Y.   +10 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Recombinant rat heat shock protein 70 (rrHSP70) may promote remyelination by regulating microglia/macrophages and oligodendrocytes in a toxin-induced demyelination animal model. [PDF]

Front Immunol
Song J, Wang J, Li Y, Wang H, Li M, Huang F, Zhang X, Wan D, Ye J, Zhou K, Yang L, Li H, Zhang C, Sun T, Wan Q, Hou S, Leng C, Wang P.   +17 more
europepmc   +1 more source

Diagnostic value of plasma heat shock protein 90α and inflammatory markers in prostate cancer. [PDF]

Front Oncol
Zhang W, Miao Y, Liu L.
europepmc   +1 more source

Characterization of Heat Shock Protein Expression and Its Application to Temporal Gene Expression in the Nematode Pristionchus pacificus. [PDF]

Dev Growth Differ
Ishita Y, Hiraga H, Chihara T, Okumura M.   +3 more
europepmc   +1 more source

Food Deprivation in <i>Triatoma pallidipennis</i> Increases the Expression of α-Tubulin, β-Actin, and a Heat Shock Protein in the Anterior Midgut. [PDF]

Pathogens
Reynoso-Ducoing OA, Díaz-Ramírez EG, Torres-Gutiérrez E, Vences-Blanco MO, González-Rete B, Guevara-Gómez Y, Cabrera-Bravo M, Salazar-Schettino PMS.   +7 more
europepmc   +1 more source

Heat shock protein Gp96 (Grp94) in malaria: functional insights at the host-parasite interface and therapeutic perspectives. [PDF]

Front Cell Dev Biol
Djoumoi D, Diouara AAM, Diop M, Nguer CM, Mbengue B, Thiam F.   +5 more
europepmc   +1 more source

High density-lipoprotein regulates liquid-liquid phase separation of heat shock protein β-1 by lncRNA HDRACA to affect vascular inflammation and atherosclerosis. [PDF]

Int J Biol Sci
Mo ZW, Liu YF, Zhang YX, Li Y, Cao Y, Liu CY, Li L, Kang YT, Cao HY, Ma ZS, Peng YM, Ou ZJ, Chang GQ, Ou JS.   +13 more
europepmc   +1 more source

RETRACTION: Novel C-Terminal Heat Shock Protein 90 Inhibitors Target Breast Cancer Stem Cells and Block Migration, Self-Renewal, and Epithelial-Mesenchymal Transition. [PDF]

Mol Oncol
europepmc   +1 more source