Results 21 to 30 of about 467,674 (297)

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
AL Rerole, Alan G. Pockley, Andreas Kirschner, Axel Walch, Brigitte T. Doß, C Botzler, C Botzler, C Gross, D Kaiserman, D Schilling, DR Ciocca, E Schmitt, FC Kurschus, G MacDonald, G Multhoff, G Multhoff, Gabriele Multhoff, Gemma A. Foulds, H Dertinger, J Friedrich, J Friedrich, J Nylandsted, J Sun, J Thiery, JA Trapani, K Pfister, L Chavez-Galan, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Wang, Mathias Gehrmann, Michael Platten, MS Buzza, RZ Lin, S Balkow, S Mahrus, S Stangl, S Stangl, SP Cullen, Stefan Stangl, SW Krause, U Giesubel, V Milani, WA Boivin, Wolfgang Sievert, Y Liu, Y Liu, Z Xia   +50 more
core   +12 more sources

Heat shock modulates neutrophil motility in zebrafish. [PDF]

PLoS ONE, 2013
Heat shock is a routine method used for inducible gene expression in animal models including zebrafish. Environmental temperature plays an important role in the immune system and infection progression of ectotherms.
Pui-ying Lam, Elizabeth A Harvie, Anna Huttenlocher   +2 more
doaj   +1 more source

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

Scientific Reports, 2021
Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB).
Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet   +14 more
doaj   +1 more source

Polycomb response elements reduce leaky expression of Cas9 under temperature-inducible Hsp70Bb promoter in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2023
Heat-shock-inducible expression of genes through the use of heat-inducible promoters is commonly used in research despite leaky expression of downstream genes of interest without targeted induction (i.e. heat shock).
Natalie Warsinger-Pepe, Carly Chang, Connor R Desroberts, Omar S Akbari   +3 more
doaj   +1 more source

Non-specific protein modifications by a phytochemical induce heat shock response for self-defense. [PDF]

PLoS ONE, 2013
Accumulated evidence shows that some phytochemicals provide beneficial effects for human health. Recently, a number of mechanistic studies have revealed that direct interactions between phytochemicals and functional proteins play significant roles in ...
Kohta Ohnishi, Shinya Ohkura, Erina Nakahata, Akari Ishisaka, Yoshichika Kawai, Junji Terao, Taiki Mori, Takeshi Ishii, Tsutomu Nakayama, Noriyuki Kioka, Shinya Matsumoto, Yasutaka Ikeda, Minoru Akiyama, Kazuhiro Irie, Akira Murakami   +14 more
doaj   +1 more source

Differential expression of heat shock protein 90, 70, 60 in chicken muscles postmortem and its relationship with meat quality [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective The aim of this study was to investigate the expression of heat shock protein (HSP) 90, 70, and 60 in chicken muscles and their possible relationship with quality traits of meat. Methods The breast muscles from one hundred broiler chickens were
Muhan Zhang, Daoying Wang, Zhiming Geng, Chong Sun, Huan Bian, Weimin Xu, Yongzhi Zhu, Pengpeng Li   +7 more
doaj   +1 more source

Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? [PDF]

, 2001
For many years, heat shock or stress proteins have been regarded as intracellular molecules that have a range of housekeeping and cytoprotective functions, only being released into the extracellular environment in pathological situations such as necrotic
Pockley, A.G.
core   +1 more source

Thermodynamics of Heat Shock Response [PDF]

, 1999
Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to T minus 7 ...
A. Gragarov, A. Hansen, C. A. Gross, D. B. Straus, D. B. Straus, F. C. Neidhardt, G. M. Makhatadze, J. S. McCarthy, K. Tilly, K. Tilly, Kim Sneppen, Kristine Bourke Arnvig, M. T. Morita, P. L. Privalov, S. L. Herendeen, S. Lindquist, S. Pedersen, S. Reeh, Steen Pedersen, Y. Zhou   +19 more
core   +2 more sources

Transient intracellular acidification regulates the core transcriptional heat shock response

eLife, 2020
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou, Christopher D Katanski, Aaron R Dinner, D Allan Drummond   +3 more
doaj   +1 more source

A role for glyceraldehyde-3-phosphate dehydrogenase in the development of thermotolerance in Xenopus laevis embryos [PDF]

, 1988
During heat shock, Xenopus laevis embryos exhibit an increase in the rate of accumulation of lactate and a loss of ATP relative to non-heat- shocked control embryos.
Browder, Leon W., Nickells, Robert W.
core   +2 more sources