Membrane heat shock protein 70: a theranostic target for cancer therapy
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 Members of the 70 kDa stress protein family are found in nearly all subcellular compartments of nucleated cells where they fulfil a number of chaperoning functions.
M. Shevtsov, Gao Huile, G. Multhoff
semanticscholar +1 more source
The Immunosuppressive Activity of Heat Shock Protein 70 [PDF]
Autoimmune Diseases, 2012 Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine. The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic peptides, which, when cross presented, elicited a T cell mediated antitumour response.
Pawel Stocki, Anne M. Dickinson
openaire +3 more sources
The Link That Binds: The Linker of Hsp70 as a Helm of the Protein’s Function
Biomolecules, 2019 The heat shock 70 (Hsp70) family of molecular chaperones plays a central role in maintaining cellular proteostasis. Structurally, Hsp70s are composed of an N-terminal nucleotide binding domain (NBD) which exhibits ATPase activity, and a C-terminal ...
Graham Chakafana +2 more
doaj +1 more source
Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]
, 1991 Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Ansorge +36 more
core +1 more source
Effects of early age feed restriction and heat conditioning on heterophil/lymphocyte ratios, heat shock protein 70 expression and body temperature of heat-stressed broiler chickens [PDF]
, 2003 We examined the effects of early age feed restriction and heat conditioning on heterophil/lymphocyte ratios (HLR), heat shock protein (hsp) 70 expression and body temperature of heat-stressed male broiler chickens.
Bejo, Mohd Hair +4 more
core +1 more source
Circulating Heat Shock Protein 70 in Health, Aging and Disease
BMC Immunology, 2011 Background Heat shock proteins (Hsp) are ubiquitously synthesised in virtually all species and it is hypothesised that they might have beneficial health effects.
Demanet Christian +5 more
doaj +1 more source
Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein. [PDF]
PLoS Pathogens, 2013 In most organisms, the heat-shock response involves increased heat-shock gene transcription. In Kinetoplastid protists, however, virtually all control of gene expression is post-transcriptional.
Dorothea Droll +6 more
doaj +1 more source
Responses of heat shock protein 70 and caspase-3/7 to dietary selenomethionine in juvenile white sturgeon. [PDF]
, 2016 An 8-week feeding trial was conducted to investigate the responses of juvenile white sturgeon (Acipenser transmontanus) to elevated dietary selenium (Se) based on the determination of the RNA/DNA ratio in muscle, heat shock protein 70 (Hsp70), and ...
Deng, Dong-Fang +3 more
core +1 more source
Heat shock protein 70-associated peptides elicit specific cancer immunity
Journal of Experimental Medicine, 1993 Vaccination of mice with heat shock protein 70 (hsp70) preparations derived from the Meth A sarcoma, but not from normal tissues, renders the mice immune to a substantial challenge with Meth A sarcoma.
H. Udono, P. Srivastava
semanticscholar +1 more source
AJOG Global ReportsBACKGROUND: The stress proteins, heat shock protein 27, heat shock protein 70, and αB-crystallin, have all been detected in human serum under normal and disease conditions.
Lindsey Broberg, MD +3 more
doaj +1 more source