Results 51 to 60 of about 142,437 (293)

DNA vaccine encoding heat shock protein 90 protects from murine lupus

Arthritis Research & Therapy, 2020
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune
Aijing Liu, Fu-Dong Shi, Irun R. Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J. Quintana, Antonio La Cava   +6 more
doaj   +1 more source

Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma. [PDF]

PLoS ONE, 2013
Metastatic pheochromocytoma represents one of the major clinical challenges in the field of neuroendocrine oncology. Recent molecular characterization of pheochromocytoma suggests new treatment options with targeted therapies.
Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak   +9 more
doaj   +1 more source

Impact of Heat-Shock Protein 90 on Cancer Metastasis [PDF]

Future Oncology, 2009
Cancer metastasis is the result of complex processes, including alteration of cell adhesion/motility in the microenvironment and neoangiogenesis, that are necessary to support cancer growth in tissues distant from the primary tumor. The molecular chaperone heat-shock protein 90 (Hsp90), also termed the 'cancer chaperone', plays a crucial role in ...
Shinji, Tsutsumi, Kristin, Beebe, Len, Neckers   +2 more
openaire   +2 more sources

Heat Shock Protein 90: The Cancer Chaperone

Journal of Biosciences, 2007
Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signalling proteins, as well as multiple mutated, chimeric, and/or over-expressed signalling proteins, that promote cancer cell growth and/or survival.
openaire   +2 more sources

Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer

, 2021
Aims The mechanisms that drive breast cancer (BC) progression and poor outcome are not fully understood. The human heat shock protein 90 alpha family class A member 1 (HSP90α) encoded by the HSP90ΑA1 gene has a vital role in cellular responses to stress ...
Chitra, J., Ball, G., Aleskandarany, M., Mongan, N., Green, A., Rakha, E., Alsaleem, M., Kurozumi, S., Alsaeed, S. A., Toss, M.   +9 more
core   +1 more source

Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

BMC Cancer, 2021
Background Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be
Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou, Zhen Liu   +5 more
doaj   +1 more source

Heat Shock Protein 90 Inhibition in Lung Cancer [PDF]

Journal of Thoracic Oncology, 2008
The heat shock protein 90 (Hsp90) chaperone is required for the conformational maturation and stability of multiple oncogenic kinases that drive signal transduction and proliferation of lung cancer cells. The recent demonstration that mutant epidermal growth factor receptor is an Hsp90 client, irrespective of the presence of the secondary threonine-to ...
Shimamura, Takeshi, Shapiro, Geoffrey I.
openaire   +2 more sources

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
Stuart, Rosemary A., Neupert, Walter, Cyr, Douglas M.   +2 more
core   +1 more source

Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia.

PLoS Neglected Tropical Diseases, 2014
BackgroundHsp90 from Giardia lamblia is expressed by splicing of two independently transcribed RNA molecules, coded by genes named HspN and HspC located 777 kb apart.
Rishi Kumar Nageshan, Nainita Roy, Shatakshi Ranade, Utpal Tatu   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source