Results 41 to 50 of about 309,378 (343)

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
A Ali, A Mitchell, A Plaine, A Roetzer, A Roetzer, A Walther, A Winkler, AA Duina, AE Piispanen, Alex Andrianopoulos, Alistair J. P. Brown, AP Gasch, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, BK Jakobsen, C Csank, C Giardina, C Queitsch, C San Jose, CA Munro, Carol Munro, CH de Dios, CJ Nobile, D Chen, DA Davis, DA Smith, DF Jarosz, DF Jarosz, DF Smith, DM Arana, DR Wysong, E Kussell, E Leberer, E Nikolaou, E Roman, EA Craig, EA Elion, ET Burt, F Estruch, F Lamoth, F Navarro-Garcia, F Navarro-Garcia, F Navarro-García, F Sherman, FA Guhad, G Degols, G Wiederrecht, G Wiederrecht, GJ Gallo, H Garreau, H Lavoie, HC Causton, I Tirosh, IV Ene, J Chen, J Zou, JL Brewster, JR Blankenship, K-H Chen, LA Walker, LA Walker, LE Cowen, Leah E. Cowen, Louise Walker, M Ramsdale, M Taipale, MD Leach, MD Leach, MD Leach, MD Leach, ME Feder, Michelle D. Leach, MM Bradford, N Shulga, P Gónzalez-Párraga, P Hawle, PD Cantero, PK Sorger, PK Sorger, R Alonso-Monge, R Alonso-Monge, R Diez-Orejas, RA Monge, RB Wilson, RS Hegde, RS Shapiro, S Bates, S Diezmann, S Kuge, S Nicholls, S Nicholls, S Nicholls, SD Singh, SH Millson, SK Prill, SL LaFayette, SL Rutherford, SM Noble, SM O'Rourke, SM Roe, Susan Budge, TT Wimalasena, VM Bruno, VM Bruno, WA Fonzi, WM Toone, X Zhang, Y Guo, Y Kamada   +110 more
core   +6 more sources

BIIB021: A novel inhibitor to heat shock protein 90–addicted oncology

Tumor Biology, 2017
Heat shock protein 90 is induced in response to the cell stress. Its overexpression has been reported in many cancers with poor prognosis. It acts as a chaperone to the client proteins, especially the activated oncoproteins in malignancies to protect ...
Liang Yan, Weiming Zhang, Beibei Zhang, Chao Xuan, Daogang Wang   +4 more
doaj   +1 more source

Early redox activities modulate Xenopus tail regeneration. [PDF]

, 2018
Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando, Luxardi, Guillaume, Raghunathan, VijayKrishna, Zhao, Min, Zhu, Kan   +4 more
core   +2 more sources

Impact of Heat-Shock Protein 90 on Cancer Metastasis [PDF]

Future Oncology, 2009
Cancer metastasis is the result of complex processes, including alteration of cell adhesion/motility in the microenvironment and neoangiogenesis, that are necessary to support cancer growth in tissues distant from the primary tumor. The molecular chaperone heat-shock protein 90 (Hsp90), also termed the 'cancer chaperone', plays a crucial role in ...
Shinji, Tsutsumi, Kristin, Beebe, Len, Neckers   +2 more
openaire   +2 more sources

Heat shock protein 90 inhibition: rationale and clinical potential

Therapeutic Advances in Medical Oncology, 2012
Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic ...
Robert B. Den, Bo Lu
doaj   +1 more source

Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells [PDF]

, 2012
Polyphenols are known to exhibit wide spectrum of benefit for brain health and to protect from several neurodegenerative diseases. The present study was sought to determine the neuroprotective effects of Rosmarinus officinalis’ polyphenols (luteolin ...
Abdrabbah Manef Ben, Han Junkyu, Isoda Hiroko, Omri Abdelfatteh E. L., 礒田 博子, 韓 畯奎   +5 more
core   +1 more source

Heat Shock Protein 90: The Cancer Chaperone

Journal of Biosciences, 2007
Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signalling proteins, as well as multiple mutated, chimeric, and/or over-expressed signalling proteins, that promote cancer cell growth and/or survival.
openaire   +2 more sources

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure [PDF]

, 2013
Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress.
A Asea, A Asea, A Asea, A Asea, A Burton, AG Pockley, Alex Dennis, AM Watkins, AP Gagge, AT Garrett, AT Garrett, AT Garrett, B Drust, B Nielsen, D Gagnon, DB Dill, DOF Canada, DS Moran, DS Moran, E Fehrenbach, E Fehrenbach, E Giraldo, E Ortega, EM Winter, F Amorim, FDC Magalhães, FT Amorim, G Borg, G Multhoff, GA Selkirk, GA Selkirk, GI Lancaster, GI Lancaster, GI Lancaster, HC Marshall, HH Kampinga, J Campisi, JD Johnson, JD Périard, JP McClung, JV Durnin, K Anbarasi, K Ogawa, KD Singleton, L Taylor, L Taylor, L Taylor, L Taylor, LA Mizzen, LB Rowell, Lee Taylor, LL Hom, M Fleshner, M Iguchi, M Whitham, M Whitham, MA Febbraio, ME Sandström, ME Sandström, MN Sawka, Neil S. Maxwell, Oliver R. Gibson, P-Z Lu, PA Ruell, Peter W. Watt, PM Yamada, R Duffield, R Morimoto, R Njemini, RC Walsh, RJ Maughan, RW Hubbard, S Lorenzo, S Lorenzo, SDR Galloway, SG Rhind, SN Cheuvront, Tony Parfitt, WE Siri, WJ Welch, Y Ogura, Y Oishi   +81 more
core   +1 more source

Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia.

PLoS Neglected Tropical Diseases, 2014
BackgroundHsp90 from Giardia lamblia is expressed by splicing of two independently transcribed RNA molecules, coded by genes named HspN and HspC located 777 kb apart.
Rishi Kumar Nageshan, Nainita Roy, Shatakshi Ranade, Utpal Tatu   +3 more
doaj   +1 more source

Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

BMC Cancer, 2021
Background Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be
Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou, Zhen Liu   +5 more
doaj   +1 more source