Results 21 to 30 of about 137,496 (252)

Heat shock protein 90: a capacitor or a mutator? [PDF]

Journal of Biosciences, 2010
ISSN:0250 ...
Sawarkar, Ritwick, Paro, Renato
openaire   +5 more sources

Heat Shock Protein 70 and 90 Family in Prostate Cancer

Life, 2022
Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang   +4 more
doaj   +1 more source

Evaluation of antioxidant property of heat shock protein 90 from duck muscle [PDF]

Animal Bioscience, 2021
Objective The objectives of this study were to investigate the direct antioxidative effect of 90 Kda heat shock protein (Hsp90) obtained from duck muscle.
Muhan Zhang, Daoying Wang, Xinglian Xu, Weimin Xu   +3 more
doaj   +1 more source

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Pharmaceutical Biology, 2022
Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han   +7 more
doaj   +1 more source

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer

Pharmaceuticals, 2012
Hsp90 is an abundant protein in mammalian cells. It forms several discrete complexes, each containing distinct groups of co-chaperones that assist protein folding and refolding during stress, protein transport and degradation. It interacts with a variety
Christos A. Papadimitriou, Konstantinos Koutsoukos, Evangelos Bournakis, Flora Zagouri   +3 more
doaj   +1 more source

Activity of the heat shock protein 90 inhibitor ganetespib in melanoma. [PDF]

PLoS ONE, 2013
Heat shock protein 90 (HSP90) is involved in the regulation of diverse biological processes such as cell signaling, proliferation and survival, and has been recently recognized as a potential target for cancer therapy.
Xinqi Wu, Melina E Marmarelis, F Stephen Hodi   +2 more
doaj   +1 more source

Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know

Biomolecules, 2022
“Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone Machine (Monastery Seeon, Germany).
Daniel Jay, Yongzhang Luo, Wei Li
doaj   +1 more source

Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma. [PDF]

PLoS ONE, 2013
Metastatic pheochromocytoma represents one of the major clinical challenges in the field of neuroendocrine oncology. Recent molecular characterization of pheochromocytoma suggests new treatment options with targeted therapies.
Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak   +9 more
doaj   +1 more source

Heat Shock Protein 90 Inhibitors repurposed against Entamoeba histolytica

Frontiers in Microbiology, 2015
Hsp90 is an essential chaperone responsible for trafficking a vast array of client proteins, which are substrates that Hsp90 regulates in eukaryotic cells under stress conditions.
Dea eShahinas, Anjan eDebnath, Christan eBenedict, James H McKerrow, Dylan R Pillai   +4 more
doaj   +1 more source

DNA vaccine encoding heat shock protein 90 protects from murine lupus

Arthritis Research & Therapy, 2020
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune
Aijing Liu, Fu-Dong Shi, Irun R. Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J. Quintana, Antonio La Cava   +6 more
doaj   +1 more source