Results 21 to 30 of about 142,437 (293)
Heat shock protein 90: biological functions, diseases, and therapeutic targets [PDF]
MedCommHeat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It collaborates
Huiyun Wei +7 more
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Effects of Heat Shock Protein 90 Inhibition In the Lungs
Medicine in Drug Discovery, 2020 Inhibition of Hsp90 is associated with anti-inflammatory effects. We employed human lung microvascular endothelial cells to investigate the effects of the Hsp90 inhibitors 17-AAG, AUY-922 and 17-DMAG in the unfolded protein response (UPR) and viability ...
Mohammad A. Uddin +5 more
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Heat shock protein 90 inhibition: rationale and clinical potential
Therapeutic Advances in Medical Oncology, 2012 Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic ...
Robert B. Den, Bo Lu
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Correction: Activity of the Heat Shock Protein 90 Inhibitor Ganetespib in Melanoma. [PDF]
PLoS ONE[This corrects the article DOI: 10.1371/journal.pone.0056134.].
Xinqi Wu +2 more
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Localization of 90-kDa heat shock protein in the kidney
Kidney International, 1990 Antibody against 90-kDa heat shock protein (HSP 90) was produced in rabbits. The obtained antibody was highly specific to the antigen. Using the antibody, the intrarenal distribution of HSP 90 was studied in frozen sections of normal rat kidneys by fluorescent and enzymic immunohistochemistry.
Matsubara, Osamu +4 more
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Phosphorylation of the 90 kDa heat shock protein in heat shocked HeLa cell lysates
FEBS Letters, 1988 The 90 kDa heat shock protein (hsp 90) is a major phosphorylated protein under normal growth conditions. However, it does not incorporate detectable levels of phosphate by incubation of control HeLa cell lysates with [γ‐32P]ATP in vitro. In this paper we show that strong phosphorylation of hsp 90 occurs in lysates prepared from heat shocked HeLa cells.
Legagneux, Vincent +3 more
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Heat shock proteins: a therapeutic target worth to consider [PDF]
Veterinary World, 2015 Heat shock proteins (HSPs) are the molecular chaperones, that are not only expressed during the normal growth process of cell cycle consecutively, but also get induced in cells during various stress conditions produced by cellular insult, environmental ...
Amita Dubey +3 more
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Heat Shock Protein 90 in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation of the intracellular microtubule ...
Jiang-Rong Ou +4 more
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Evaluation of Plasma Heat Shock Protein Levels in Smokers
Addicta: The Turkish Journal on Addictions, 2022 This study aims to evaluate the effects of smoking on extracellular heat shock protein levels. Heat shock proteins have been associated with numerous diseases.
Muhammet Kızmaz +3 more
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Differential expression of heat shock protein 90, 70, 60 in chicken muscles postmortem and its relationship with meat quality [PDF]
Asian-Australasian Journal of Animal Sciences, 2017 Objective The aim of this study was to investigate the expression of heat shock protein (HSP) 90, 70, and 60 in chicken muscles and their possible relationship with quality traits of meat. Methods The breast muscles from one hundred broiler chickens were
Muhan Zhang +7 more
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