Results 31 to 40 of about 142,437 (293)

Bioresistive identification of heat shock protein 90 [PDF]

Biomicrofluidics, 2008
90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to
Arvind, Chandrasekaran, Shanmugasundaram, Pakkiriswami, Jian Liang, You, Ashwin, Acharya, Muthukumaran, Packirisamy, Denis, Maxwell   +5 more
openaire   +2 more sources

Crowding Activates Heat Shock Protein 90 [PDF]

Journal of Biological Chemistry, 2016
Hsp90 is a dimeric ATP-dependent chaperone involved in the folding, maturation, and activation of diverse target proteins. Extensive in vitro structural analysis has led to a working model of Hsp90's ATP-driven conformational cycle. An implicit assumption is that dilute experimental conditions do not significantly perturb Hsp90 structure and function ...
Jackson C, Halpin, Bin, Huang, Ming, Sun, Timothy O, Street   +3 more
openaire   +2 more sources

Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle?

Frontiers in Veterinary Science, 2022
BackgroundHeat stress (HS) in cattle is a major debilitating problem, affecting health and milk yield. Physiologically, HS has been shown to lower blood glucose levels to 2.5 mmol/l (45 mg/dl) and results in upregulation of heat shock proteins (HSPs ...
Samuel A. Atkin, Abu Saleh Md Moin, Stephen L. Atkin, Alexandra E. Butler   +3 more
doaj   +1 more source

Heat shock protein 90: a capacitor or a mutator? [PDF]

Journal of Biosciences, 2010
ISSN:0250 ...
Sawarkar, Ritwick, Paro, Renato
openaire   +5 more sources

Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation

Frontiers in Immunology, 2023
IntroductionChronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an unsatisfactory response or side effects.
Hakim Ben Abdallah, Sabine Seeler, Anne Bregnhøj, Gautam Ghatnekar, Lasse S. Kristensen, Lars Iversen, Claus Johansen   +6 more
doaj   +1 more source

Heat Shock Protein 70 and 90 Family in Prostate Cancer

Life, 2022
Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang   +4 more
doaj   +1 more source

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar, George A. C. Murrell, Millar, N.L., Murrell, G.A.C.   +3 more
core   +1 more source

Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation [PDF]

, 2008
Introduction The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and functional differentiation of the mammary gland.
Liu, R., Bork, Peer, Shemanko, Carrie S., Shemanko, C., Liu, Ruixuan, Pfitzner, Edith, Schultz, J., Christine T Parusel, Jörg Schultz, Groner, Bernd, Parusel, Christine T., Bork, P., Boecher, N., Perotti, Christian, Christian Perotti, Ruixuan Liu, Carrie S Shemanko, Pfitzner, E., Groner, B., Schultz, Jörg, Bernd Groner, Böcher, Nadine, Nadine Böcher, Perotti, C., Peer Bork, Edith Pfitzner, Parusel, C.   +26 more
core   +1 more source

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Ashworth, R, Prodromou, NV, Osborn, DP, Chapple, JP, Beales, PL, Knight, MM, Thompson, CL, Cogger, KF   +7 more
core   +1 more source

Mebendazole’s Conformational Space and its Predicted Binding to Human Heat-Shock Protein 90

, 2022
Recent experimental evidence suggest that mebendazole, a popular antiparasitic drug, binds to heat shock protein 90 (Hsp90) and inhibit acute myeloid leukemia cell growth.
Jasmin, Wellbrock, Walter, Fiedler, Karl, Kirschner, Fabian, Freisleben   +3 more
core   +1 more source