Heat shock protein 90 inhibition in the endothelium [PDF]
Frontiers in Medicine, 2023 Nektarios Barabutis
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Heat shock protein 90 in neurodegenerative diseases [PDF]
Molecular Neurodegeneration, 2010 Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy, recent evidence from several laboratories suggests a role for Hsp90 in maintaining the functional ...
Rodina Anna +4 more
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Functional interplay between heat shock protein 90 (HSP90) and heat shock factors (HSFs) [PDF]
Cell Stress & ChaperonesMaintenance of protein homeostasis, also known as proteostasis, is essential for cellular survival under both basal and stress conditions. Proteostasis relies on a coordinated action between molecular chaperones, such as heat shock proteins (HSPs), and ...
Abir Chakraborty +2 more
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Heat Shock Protein 90 regulates encystation in Entamoeba [PDF]
Frontiers in Microbiology, 2015 Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection worldwide with high morbidity and mortality. Even though the clinical burden of this parasite is very high, this infection is categorized as a neglected disease.
Meetali eSingh +3 more
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The hexameric structures of human heat shock protein 90. [PDF]
PLoS ONE, 2011 The human 90-kDa heat shock protein (HSP90) functions as a dimeric molecular chaperone. HSP90 identified on the cell surface has been found to play a crucial role in cancer invasion and metastasis, and has become a validated anti-cancer target for drug ...
Cheng-Chung Lee +3 more
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Heat shock protein 90 has roles in intracellular calcium homeostasis, protein tyrosine phosphorylation regulation, and progesterone-responsive sperm function in human sperm. [PDF]
PLoS ONE, 2014 Heat shock protein 90 plays critical roles in client protein maturation, signal transduction, protein folding and degradation, and morphological evolution; however, its function in human sperm is not fully understood.
Kun Li +7 more
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The development of cancers research based on mitochondrial heat shock protein 90 [PDF]
Frontiers in Oncology, 2023 Mitochondrial heat shock protein 90 (mtHsp90), including Tumor necrosis factor receptor-associated protein 1 (TRAP1) and Hsp90 translocated from cytoplasm, modulating cellular metabolism and signaling pathways by altering the conformation, activity, and ...
Yuchu Xiang +9 more
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A secreted Heat shock protein 90 of Trichomonas vaginalis. [PDF]
PLoS Neglected Tropical Diseases, 2018 Trichomonas vaginalis is a causative agent of Trichomoniasis, a leading non-viral sexually transmitted disease worldwide. In the current study, we show Heat shock protein 90 is essential for its growth. Upon genomic analysis of the parasite, it was found
Meetali Singh +7 more
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Heat shock protein 90 is a chaperone regulator of HIV-1 latency. [PDF]
PLoS PathogensAn estimated 32 million people live with HIV-1 globally. Combined antiretroviral therapy suppresses viral replication but therapy interruption results in viral rebound from a latent reservoir mainly found in memory CD4+ T cells.
Somaya Noorsaeed +3 more
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BIIB021: A novel inhibitor to heat shock protein 90–addicted oncology
Tumor Biology, 2017 Heat shock protein 90 is induced in response to the cell stress. Its overexpression has been reported in many cancers with poor prognosis. It acts as a chaperone to the client proteins, especially the activated oncoproteins in malignancies to protect ...
Liang Yan +4 more
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