Results 11 to 20 of about 137,496 (252)
Heat shock protein 90 in neurodegenerative diseases [PDF]
Molecular Neurodegeneration, 2010 Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy, recent evidence from several laboratories suggests a role for Hsp90 in maintaining the functional ...
Rodina Anna +4 more
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The hexameric structures of human heat shock protein 90. [PDF]
PLoS ONE, 2011 The human 90-kDa heat shock protein (HSP90) functions as a dimeric molecular chaperone. HSP90 identified on the cell surface has been found to play a crucial role in cancer invasion and metastasis, and has become a validated anti-cancer target for drug ...
Cheng-Chung Lee +3 more
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A secreted Heat shock protein 90 of Trichomonas vaginalis. [PDF]
PLoS Neglected Tropical Diseases, 2018 Trichomonas vaginalis is a causative agent of Trichomoniasis, a leading non-viral sexually transmitted disease worldwide. In the current study, we show Heat shock protein 90 is essential for its growth. Upon genomic analysis of the parasite, it was found
Meetali Singh +7 more
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Heat Shock Protein 90 regulates encystation in Entamoeba [PDF]
Frontiers in Microbiology, 2015 Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection worldwide with high morbidity and mortality. Even though the clinical burden of this parasite is very high, this infection is categorized as a neglected disease.
Meetali eSingh +3 more
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Effects of Heat Shock Protein 90 Inhibition In the Lungs
Medicine in Drug Discovery, 2020 Inhibition of Hsp90 is associated with anti-inflammatory effects. We employed human lung microvascular endothelial cells to investigate the effects of the Hsp90 inhibitors 17-AAG, AUY-922 and 17-DMAG in the unfolded protein response (UPR) and viability ...
Mohammad A. Uddin +5 more
doaj +3 more sources
Heat Shock Protein 90 in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation of the intracellular microtubule ...
Jiang-Rong Ou +4 more
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Bioresistive identification of heat shock protein 90 [PDF]
Biomicrofluidics, 2008 90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to
Arvind, Chandrasekaran +5 more
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Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle?
Frontiers in Veterinary Science, 2022 BackgroundHeat stress (HS) in cattle is a major debilitating problem, affecting health and milk yield. Physiologically, HS has been shown to lower blood glucose levels to 2.5 mmol/l (45 mg/dl) and results in upregulation of heat shock proteins (HSPs ...
Samuel A. Atkin +3 more
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Crowding Activates Heat Shock Protein 90 [PDF]
Journal of Biological Chemistry, 2016 Hsp90 is a dimeric ATP-dependent chaperone involved in the folding, maturation, and activation of diverse target proteins. Extensive in vitro structural analysis has led to a working model of Hsp90's ATP-driven conformational cycle. An implicit assumption is that dilute experimental conditions do not significantly perturb Hsp90 structure and function ...
Jackson C, Halpin +3 more
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Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation
Frontiers in Immunology, 2023 IntroductionChronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an unsatisfactory response or side effects.
Hakim Ben Abdallah +6 more
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