Results 161 to 170 of about 211,923 (255)

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Dissecting the impact of heat stress on heat-shock response and skin microbiota in farmed fish in a recirculating aquaculture system in Singapore. [PDF]

Microbiol Spectr
Ng TH, M S, Chew XZ, Nair T, Chow JW, Low A, Seedorf H, Bastos Gomes G.   +7 more
europepmc   +1 more source

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response. [PDF]

Pharm Biol, 2022
Shen Q, Chen Q, Liu Y, Xue X, Shen X, He Q, Wang G, Han F.   +7 more
europepmc   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

A Novel Pathogenic Variant Identified in HIKESHI-Related Hypomyelinating Leukodystrophy Disrupts Heat Shock Response in iPSCs. [PDF]

Int J Mol Sci
Saleh MA, Boichuck M, Ottolenghi A, Rabinski T, Goldenthal O, Sanchez DS, Fattal-Valevski A, Heimer G, Ben-Shachar S, Libzon S, Gershoni-Yahalom O, Ben-Zvi A, Zarivach R, Zerem A, Rosental B, Vatine GD.   +15 more
europepmc   +1 more source

Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response. [PDF]

J Virol, 2023
Huang JR, Arii J, Hirai M, Nishimura M, Mori Y.   +4 more
europepmc   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

Advanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim, Wonsik Kim, Wansun Kim, Yeon‐Hee Kim, Samjin Choi, Jang Hwan Kim, Hyeong Min Jin   +6 more
wiley   +1 more source

Resveratrol protects male <i>Drosophila melanogaster</i> from heat stress-induced paralysis through a mechanism independent of heat shock response activation. [PDF]

MicroPubl Biol
Webb N, Bricker R, Skalos T, Choi A, Shirk A, Hrizo SL, Buckley MS.   +6 more
europepmc   +1 more source

Engineering Synergistic Intra‐/Intermolecular Conformational Locking via Side‐Chain Branching: A β‐Sheet‐Inspired Strategy for Planar NIR‐II Phototheranostic Aggregates

Advanced Science, EarlyView.
A bio‐inspired side‐chain branching strategy is developed to orchestrate a dual noncovalent conformational locking (NoCL) network, enabling the construction of perfectly planar NIR‐II phototheranostic aggregates. Such structural precision maximizes light‐harvesting efficiency and optimizes exciton dynamics, ensuring synchronized enhancements in NIR‐II ...
Cheng Lu, Qian Jia, Bo Wu, Chao Li, Ryan T. K. Kwok, Tie‐Gen Chen, Jianwei Sun, Zheng Zhao, Teng‐Teng Chen, Zhongliang Wang, Jacky W. Y. Lam, Ben Zhong Tang   +11 more
wiley   +1 more source

Preserve or destroy: Orphan protein proteostasis and the heat shock response. [PDF]

J Cell Biol
Ali A, Paracha S, Pincus D.
europepmc   +1 more source