Results 161 to 170 of about 6,994,266 (255)

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Modulation of host proteostasis by Prevotella corporis via induction of the heat shock response. [PDF]

Cell Stress Chaperones
Tibi MF, Argote YM, Walker AC, Pandey S, Puente C, Ellward GL, Safwat A, Rincon-Limas DE, Czyż DM.   +8 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Functional impact of a conservative missense mutation in the Mycobacterium bovis BCG Moreau heat shock response regulator hrcA gene. [PDF]

BMC Microbiol
Gomes LHF, Antunes D, Correa PR, Schwarz MGA, Mendonça-Lima L.   +4 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Characterisation of the thermal and non-thermal stress conditions that activate the Plasmodium falciparum AP2-HS-dependent heat-shock response. [PDF]

PLoS Pathog
Ràfols N, Nyarko PB, Chillarón-Adán M, Tintó-Font E, Cortés A.   +4 more
europepmc   +1 more source

Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response. [PDF]

Elife, 2023
Garde R, Singh A, Ali A, Pincus D.
europepmc   +1 more source

Regulation of small heat shock protein genes expression by heat shock factors transcriptome in Arabidopsis

, 2007
熱休克反應為生物體內普遍存在的逆境抵抗機制，會誘導數群分子量不同的熱休克蛋白質(heat shock protein, HSP)產生，以進行細胞保護。植物中低分子量熱休克蛋白質(small HSP, sHSP)的累積與種類是已知物種最多的一群HSP。關於高溫誘導表現的機制，已知會由一群熱休克因子(heat shock factor, HSF)來調控。阿拉伯芥與水稻中，分別具有包含A、B、C三個類群的21個和25個HSF基因成員，顯示在高等生物對於HSP表現的調控極為複雜 ...
李宗遠, Lee, Tsung-Yuan
core  

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response. [PDF]

Nat Commun
Omkar S, Kline JT, Grissom JH, Sun D, Chi RJ, Bard JAM, Fornelli L, Truman AW.   +7 more
europepmc   +1 more source