Results 171 to 180 of about 6,994,266 (255)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Conservation of mRNA operon formation in control of the heat shock response in mammalian cells. [PDF]

Sci Adv
Pataki E, Gerst JE.
europepmc   +1 more source

Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response. [PDF]

Cells, 2023
Crake R, Gasmi I, Dehaye J, Lardinois F, Peiffer R, Maloujahmoum N, Agirman F, Koopmansch B, D'Haene N, Azurmendi Senar O, Arsenijevic T, Lambert F, Peulen O, Van Laethem JL, Bellahcène A.   +14 more
europepmc   +1 more source

Unlocking Low‐Melting‐Point and High‐Conductivity Molten Salts via High‐Entropy Strategy with Demonstration in Thermal Batteries

Advanced Science, EarlyView.
A high‐entropy strategy is developed to break the trade‐off between low melting point and high ionic conductivity in molten salt electrolytes. By incorporating CsBr and LiF into the LiCl‐LiBr‐KBr system, the quinary LiF‐LiCl‐LiBr‐KBr‐CsBr electrolyte achieves a record‐low melting point of 229.5°C while maintaining a high conductivity of 1.19 S cm−1 at ...
Binchao Shi, Ting Sun, Fushan Yu, Yi Zhang, Gaowu Wang, Ting Quan, Yan‐li Zhu   +6 more
wiley   +1 more source

γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response. [PDF]

BMC Plant Biol
Wang Y, Wang J, Wang F, Meng T, Liu X, Ruan B, Wu L, Yu Y, Chen F.   +8 more
europepmc   +1 more source

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models. [PDF]

Mol Neurobiol, 2023
Ahmed M, Spicer C, Harley J, Taylor JP, Hanna M, Patani R, Greensmith L.   +6 more
europepmc   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

The Neuronal Heat Shock Response

Heat shock, which refers to abrupt increases in environmental temperature, induces a cascade of cellular stress responses called the heat shock response (HSR).
Seluzicki, Caitlin Marie
core   +1 more source

TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress. [PDF]

Nat Commun
Shukla N, Neal ML, Farré JC, Mast FD, Sarkar R, Truong L, Simon T, Miller LR, Aitchison JD, Subramani S.   +9 more
europepmc   +1 more source

HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways. [PDF]

J Biol Chem, 2023
Silveira MAD, Khadangi F, Mersaoui SY, Naik D, Masson JY, Bilodeau S.   +5 more
europepmc   +1 more source