Results 71 to 80 of about 870,730 (334)

The heat shock response restricts virus infection in Drosophila

Scientific Reports, 2015
Innate immunity is the first line of defence against pathogens and is essential for survival of the infected host. The fruit fly Drosophila melanogaster is an emerging model to study viral pathogenesis, yet antiviral defence responses remain poorly ...
S. Merkling, Gijs J. Overheul, J. V. van Mierlo, Daan W. Arends, C. Gilissen, R. V. van Rij   +5 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Characterizing primary transcriptional responses to short term heat shock in Down syndrome.

PLoS ONE
Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21.
Joseph F Cardiello, Jessica Westfall, Robin Dowell, Mary Ann Allen   +3 more
doaj   +1 more source

Prior exposure strongly influences mechanisms underpinning survival of heat shock in Escherichia coli

Frontiers in Microbiology
The heat shock response of Escherichia coli represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation.
Muhammad Yasir, Muhammad Yasir, A. Keith Turner, A. Keith Turner, Sarah Bastkowski, Sarah Bastkowski, Caroline S. Jarvis, Caroline S. Jarvis, Caroline S. Jarvis, Ryan Sweet, Ryan Sweet, Megan Truong, Megan Truong, Megan Truong, Megan Truong, Ian G. Charles, Ian G. Charles, Ian G. Charles, Mark A. Webber, Mark A. Webber, Mark A. Webber   +20 more
doaj   +1 more source

Mechanism of protonophores-mediated induction of heat-shock response in Escherichia coli

BMC Microbiology, 2009
Background Protonophores are the agents that dissipate the proton-motive-force (PMF) across E. coli plasma membrane. As the PMF is known to be an energy source for the translocation of membrane and periplasmic proteins after their initial syntheses in ...
Saha Swati, Panja Subrata, Jana Bimal, Basu Tarakdas   +3 more
doaj   +1 more source

Induced Metastable Memory in Heat Shock Response [PDF]

Journal of Biological Physics, 2006
We studied the dynamics of the Heat Shock Response (HSR) mechanism, and the persistence of a injury-protected state in the cell following the shocks, known as thermotolerance. A series of double shock experiments were performed on Chinese Hamster Ovary (CHO) cells, tracking the dynamics of some components of HSR pathway (the Hsp70 protein level and ...
REMONDINI, DANIEL, BERNARDINI, CHIARA, FORNI, MONICA, BERSANI, FERDINANDO, CASTELLANI, GASTONE, BACCI, MARIA LAURA   +5 more
openaire   +3 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Heat shock modulates neutrophil motility in zebrafish. [PDF]

PLoS ONE, 2013
Heat shock is a routine method used for inducible gene expression in animal models including zebrafish. Environmental temperature plays an important role in the immune system and infection progression of ectotherms.
Pui-ying Lam, Elizabeth A Harvie, Anna Huttenlocher   +2 more
doaj   +1 more source

Developmental regulation of the heat shock response by nuclear transport factor karyopherin-α3 [PDF]

, 2001
During early stages of Drosophila development the heat-shock response cannot be induced. It is reasoned that the adverse effects on cell cycle and cell growth brought about by Hsp70 induction must outweigh the beneficial aspects of Hsp70 induction in the
Chen, Tianxin, Fang, Xiang-dong, Parker, Carl S., Tran, Kim   +3 more
core  

Effects of Carbon Nanoparticles on Triboelectro‐Induced Surface Defects

Advanced Engineering Materials, EarlyView.
Carbon nanoparticles added to grease modify the electrocontact behavior. The synergy of particle concentration and electric current dominates the surface damage of metals in contact. Electrical surface damage caused by current leakage is a critical challenge in high‐performance applications such as electric vehicle (EV) drivetrains and wind turbine ...
Mohsen Tajedini, Lu Fang, Jacob Bons, Mohammad Humaun Kabir, Evan Johnson, Joe Kosmoski, Hong Liang   +6 more
wiley   +1 more source