Results 121 to 130 of about 7,306,204 (405)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Heat Stress Impacts Immune Status in Cows Across the Life Cycle

Frontiers in Veterinary Science, 2020
Heat stress has a myriad of effects on dairy cattle across the life cycle. Whereas, the most commonly recognized impacts are associated with production responses, emerging evidence indicates that heat stress profoundly alters the immune response of ...
G. Dahl, S. Tao, J. Laporta
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Breeding for improved heat tolerance in dairy cattle: Methods, challenges, and progress*

JDS Communications
Heat tolerance in dairy cattle has likely deteriorated over time due to unfavorable genetic correlations between milk production level and heat tolerance, with stronger deterioration in later parities.
Ignacy Misztal, Luiz F. Brito, Daniela Lourenco   +2 more
doaj   +1 more source

Human temperature regulation under heat stress in health, disease, and injury.

Physiological Reviews, 2022
M. Cramer, D. Gagnon, O. Laitano, C. Crandall   +3 more
semanticscholar   +1 more source

Strategies to Combat Heat Stress in Broiler Chickens: Unveiling the Roles of Selenium, Vitamin E and Vitamin C

Veterinary Sciences, 2020
Heat stress compromises efficient poultry production by impairing growth performance and increasing mortality. Mechanisms to dissipate excess heat divert energy from efficient production.
M. Shakeri, E. Oskoueian, H. Le, Mehdi Shakeri   +3 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

On thermal stress failure of the SNAP-19A RTG heat shield [PDF]

Results of a study on thermal stress problems in an amorphous graphite heat shield that is part of the launch-abort protect system for the SNAP-19A radio-isotope thermoelectric generators (RTG) that will be used on the Viking Mars Lander are presended ...
Anderson, L. A., Pitts, W. C.
core   +1 more source

Concentric tubes cold-bonded by drawing and internal expansion [PDF]

, 1971
Metal tubes bonded together without heat application or brazing materials retain strength at elevated temperatures, and when subjected to constant or cyclic temperature gradients.
Hymes, L. C., Stone, C. C.
core   +1 more source

Transcriptome analysis of heat stress and drought stress in pearl millet based on Pacbio full-length transcriptome sequencing

BMC Plant Biology, 2020
Background Heat and drought are serious threats for crop growth and development. As the sixth largest cereal crop in the world, pearl millet can not only be used for food and forage but also as a source of bioenergy.
Min Sun, De-jun Huang, A. Zhang, I. Khan, Haidong Yan, Xiaoshan Wang, Xinquan Zhang, Jian Zhang, Linkai Huang   +8 more
semanticscholar   +1 more source