Results 71 to 80 of about 4,092,332 (300)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Riverbed Temperature and Heat Transport in a Hydropeaked River

Water Resources Research, 2021
Hydropeaking, the alternating storage and release of water from reservoirs for hydropower generation, perturbs the thermal regime of many large rivers.
Stephen B. Ferencz, Sebastian Muñoz, Bethany T. Neilson, M. Bayani Cardenas   +3 more
doaj   +1 more source

The Heat Carrier Flow Control in Heat Transport Systems

Bulletin of the South Ural State University. Ser. Computer Technologies, Automatic Control & Radioelectronics, 2016
Панферов Владимир Иванович, д-р техн. наук, профессор, зав. кафедрой теплогазоснабжения и вентиляции, Южно-Уральский государственный университет, г. Челябинск; tgsiv@mail.ru. Панферов Сергей Владимирович, канд. техн. наук, доцент кафедры теплогазоснабжения и вентиляции, Южно-Уральский государственный университет, г. Челябинск; tgsiv@mail.ru.
PANFEROV V.I., PANFEROV S.V.
openaire   +4 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Modeling of Mechanical Interaction of Reinforcement with Matrix Composite

Механика машин, механизмов и материалов, 2009
There is solved the problem on determination influence of contact parameters between composite reinforcement and a matrix on strengthening and stiffness of a supporting structure. It is executed on a finite element modelling basis.
Yu.M. Pleskachevsky , A.O. Shimanovsky , O.I. Yakubovich , G.M. Kuziomkina   +3 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Dynamics of Circular Metal-Polymeric Plates on an Elastic Foundation. Part I. FREE VIBRATIONS

Механика машин, механизмов и материалов, 2008
The axisymmetrical free vibrations of elastic circular three-layer metal-polymeric plate on en elastic foundation are explored. Reaction of foundation was described on the base of Winkler’s model.
Yu.M. Pleskatshevsky, E.I. Starovoitov , D.V. Leonenko   +2 more
doaj  

Heat Content Anomaly and Decay of Warm‐Core Rings: the Case of the Gulf of Mexico

Geophysical Research Letters, 2020
In this study, we harness the 25‐year satellite‐altimeter record, in concert with a vast array of in situ measurements, to estimate the heat content anomaly of 32 warm‐core rings in the Gulf of Mexico (GoM).
Thomas Meunier, Julio Sheinbaum, Enric Pallàs‐Sanz, Miguel Tenreiro, José Ochoa, Angel Ruiz‐Angulo, Xavier Carton, Charly de Marez   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Modeling the Operating Conditions of Electric Power Systems Feeding DC and AC Traction Substations

Energies
This paper presents the findings of the research aimed at developing computer models to determine the operating conditions in electric power systems (EPSs) feeding DC and AC railway substations.
Iliya K. Iliev, Andrey V. Kryukov, Konstantin V. Suslov, Aleksandr V. Cherepanov, Nguyen Quoc Hieu, Ivan H. Beloev, Yuliya S. Valeeva   +6 more
doaj   +1 more source